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BSI jobs board

To post a job advertisement on this page, please contact our Education & Careers Officer, Eolan Healy. Note that this service is free to BSI members and their institutions, as well as our corporate members. There is a small charge of £100 for non-members who wish to advertise. 

Please note, all job vacancies are posted as soon as they are received, and are cleared after the closing date, or after three months, if one is not specified.

For more information about the vacancies, please click on the links below. You may also find it helpful to have a look at our funding opportunities page

Current vacancies

Postdoctoral Research Scientist - Mucosal Immunology

Organisation position and purpose:

This 4-year Postdoctoral Scientist position is one of several available within the Bill and Melinda Gates Foundation-funded Pirbright Livestock Antibody Hub. This hub will exploit the recent advances in our understanding of B-cell responses to better understand the protective immune response in livestock and poultry. They will address the needs of the research community and bridge the requirements of the vaccine industry. Overall the hub will support rational vaccinology approaches, antibody-based treatment and prophylaxis as well as increasing the applicability of animals as models for human disease and treatment.

As part of this Hub, they will continue to develop specific Work Programs to enable antibody discovery, manipulation and testing in cattle, pigs and poultry. This will require the establishment of species and pathogen specific methods to interrogate antibody responses in parallel with in vivo studies in the natural host. We aim to share expertise and actively collaborate with other research centres and vaccine companies worldwide to act as a central Hub for antigen-specific antibody discovery and characterisation.

The Postdoctoral Scientist will work within the Mucosal Immunology group and work closely with a multidisciplinary team to advance the aims of the overall Pirbright Livestock Antibody Hub. The postholder will utilise a wide range of immunological and virological techniques such as FACS analysis, ELISPOT, microneutralisation, virus propagation, plaque assays and other cellular approaches to:

  1. exploit the pig as a large-animal model for influenza virus infection
  2. identify alternative mechanism of protection beyond virus neutralization
  3. help characterize the Fc receptor gene content and the understanding of the function of each Fc receptor in cattle, poultry and pigs
  4. help development a suite of assays to examine the function of individual antibodies (recombinant or native) for several species

The post-holder will report to the Head of the Mucosal Immunology group and will work with other members of the Pirbright Livestock Antibody Hub as required.

Specific requirements

Essential

  • A PhD or equivalent in a relevant branch of biosciences
  • Significant relevant postdoctoral research experience
  • An excellent record of research productivity, commensurate to the applicant’s career
  • Experience in influenza virological techniques including virus propagation and quantification, microneutralisation and haemagglutination inhibition assays
  • Experience in cellular biology
  • Experience in immunology including flow cytometry, analysis of cellular and humoral responses, ELISPOT, proliferation assays, ELISA, ADCC and ADCP
  • Evidence of effective management of students, technicians or other team members
  • Evidence of building collaborative relationships
  • Excellent oral and written communication skills, including the ability to interact effectively with funding bodies, peer-review groups and government agencies
  • An ability to prioritise tasks effectively while under pressure
  • A willingness to work outside normal working hours and to undertake travel worldwide

What we offer 

  • Generous Group Personal Pension Scheme and life cover (subject to age and earnings)
  • 25 days annual leave per annum, pro rata, plus 10.5 public and privilege days
  • Pirbright gym with subsidised membership
  • Pirbright social club
  • Pirbright Lifestyle Hub (employee discount site)
  • Cycle to work
  • Subsidised staff restaurant
  • Subsidised childcare allowance
  • Free onsite parking
Institution/Organisation:
Pirbright Institute
Application deadline:
Research Technician - Haematology & Immunology

Are you an early career researcher looking for a challenge? Do you have a background in Cancer Biology, Immunology or Virology?  Can you provide technical support to research projects? Do you want to further your career in one of the UK’s leading research-intensive Universities?

A new paradigm in virus-mediated immunotherapy for liver cancer.

University fo Leeds are seeking a research technician to work on a new approach to liver cancer immunotherapy in the laboratory of Dr Stephen Griffin. You will use a range of molecular immunology and cell biology approaches to study therapeutic immune responses to liver cancer, driven by a new virus-based immunotherapy.

Advanced liver cancer is the fastest-growing cause of cancer-related deaths worldwide and current targeted therapy extends life expectancy by only a matter of months. However, harnessing the power of our own immune systems – immunotherapy - is showing increasing promise for the treatment of otherwise incurable malignancies. Cancer-killing, or “Oncolytic” viruses are increasingly used to evoke therapeutic immune responses in cancer patients, an example of which is now commonly used to treat malignant melanoma in the skin. They have discovered that modifying a particular oncolytic virus to prevent its ability to replicate dramatically improves therapy in preclinical models of liver cancer, as well as promoting synergy with the targeted cancer drug, Sorafenib.

This four-year project, funded by the Medical Research Council (MRC), seeks to both optimise and understand how the modified virus co-operates with Sorafenib to evoke immune responses against malignant hepatocytes. In particular, it will explore the immunological mechanisms that distinguish effective therapy within both primary human liver tissue and preclinical models of liver cancer. We will employ a range of techniques spanning functional immunology, molecular virology and cell biology, histochemical and immunofluorescence tissue analysis, as well as next generation transcriptomics designed to discriminate immunological phenotypes. The objective will be to achieve comprehensive understanding of the fundamental processes by which host immune responses target liver cancers, as well as providing the foundation for future clinical studies exploring this novel therapeutic approach.

You will have a background in cancer/cell biology/immunology/virology, and an interest in applying that expertise to the study of tumour immunotherapy. You will join a team of researchers focussing on the mechanisms of virus-host interactions in the cancer field.

Institution/Organisation:
University of Leeds
Application deadline:
Research Assistant/Associate (Fixed Term)

The Thaventhiran group, within the Medical Research Council Toxicology Unit (MRC-TU), is the Cancer Immunology group, that uses human and mouse models to determine the therapeutic window of immune checkpoint blockade. Their investigation of rare patients with monogenic causes of immune dysregulation has identified a number of genes that are immune checkpoints, since their loss-of function leads to adaptive immune cell activation(1-3).

Mechanistic studies are now underway that use a novel transgenic mouse that fate-maps antigen receptor signalling, which in combination with single cell RNAseq/CITEseq can define the clonal dysfunction caused by targetting of immune pathways. This model allows us to kinetically track individual B and T cell clonal responses to any trigger across multiple tissue sites.

They are now looking to appoint a postdoctoral Research Associate to join our team in an exciting research project that uses the above systems to investigate the contribution of self-reactive lymphocytes to disease. The post will be ideal for a trained murine immunologist who is seeking experience in computational biology. However, talented candidates with a strong background in statistical methods or computational biology who are keen to develop experience in immunology are very much encouraged to apply. Additionally, the post-holder will have the freedom to develop their own projects, in line with lab interests.

The MRC-TU is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including super resolution microscopy, advanced flow-cytometry and offers excellent opportunities for postdoctoral development. The Unit is currently located at Leicester and will physically relocate to the Gleeson Building, Cambridge in 2020. This post will initially be based at the CRUK-CI, Cambridge, prior to relocation to the Gleeson Building.

Applicants must hold, or be close to completing, a PhD in a relevant discipline such as Immunology or Computational Biology. The project will require significant time working with preclinical models of immune checkpoint loss, generating single-cell RNA sequencing datasets and the computational analysis of these. A PhD student will work alongside the post-holder and complement their skills, so, working as part of a team within the laboratory environment is an essential attribute. The ability to work both independently in relation to the candidates existing expertise, together with excellent communication and critical thinking skills are also essential.

Appointment at Research Associate is dependent on having a PhD. Where a PhD has yet to be awarded or submitted appointment will initially be made as a Research Assistant and amended to Research Associate when the PhD is awarded.

Institution/Organisation:
University of Cambridge
Application deadline:
Research Associate (Immunology)

Role Description

Department

Immunology is a primary research focus within the York Biomedical Research Institute. Their work aims to reveal the molecular mechanisms underpinning immunity and immunopathology during complex infectious and non-communicable inflammatory diseases. In this context, leishmaniasis is a globally important parasitic disease with over 1M new cases each year across 98 countries. The York Biomedical Research Institute boasts one of the largest groups of researchers working on leishmaniasis in academia, with partnerships in >20 countries. Their work on leishmaniasis spans the whole spectrum from mechanistic immunology, parasite biology to human challenge and vaccination trials. This immunology post is funded by a MRC-FAPESP Joint Centre Partnership award between the University of York and the University of Sao Paulo and is funded for two years.

Role

They are seeking to appoint a postdoctoral scientist with a strong interest in mechanistic immunology to carry out research on the microenvironmental control of myeloid cell function, using single-cell transcriptomics and multiplex spatial profiling (e.g. GeoMx Digital Spatial Profiling). You will have the opportunity to work in multidisciplinary team. You will conduct an independent research project using tissue samples derived from clinical cohorts in endemic countries and from animal models of infection, whilst also working with a larger team. You will analyse and interpret research data to address timely questions in myeloid biology and identify future research directions. You will write up research results, and disseminate them through publications, lab meetings, seminar and conference presentations and public engagement activities.

Skills, Experience & Qualification needed

You will have a PhD in immunology or a related discipline and an interest in discovering molecular mechanisms driving immunity to infection. You will have knowledge of myeloid cell biology including research around heterogeneity and its relationship to function. You will have research expertise in cellular and or molecular immunology, specialist IT knowledge, knowledge of flow cytometry, imaging and or immunohistochemistry and a broad understanding of immunology/immunity to infectious disease. Knowledge of single cell profiling technologies and pipelines is desirable but not essential.

You will have an excellent track record of research evidenced through publications. You should be highly motivated, and able to engage with scientists, clinicians and other research staff to deliver your research. A willingness to travel to overseas clinical sites to assist in sample collection is essential.

Institution/Organisation:
University of York
Application deadline:
Postdoctoral Research Associate in Immunology

Are you an ambitious researcher looking for your next challenge? Do you have an established background in cellular immunology? Do you want to further your career in a world-leading laboratory working on global health that is making a real difference to the health of millions of people?

University of Edinburgh are seeking an ambitious scientist to join their dynamic research group pursuing immunology and epidemiology research to address key questions and evidence gaps in infectious and non-infectious diseases in the tropics. The post is to support the work of the Parasite Immunoepidemiology Group led by Professor Francisca Mutapi at the University of Edinburgh. In addition to human immunology research, this role involves mentoring of PhD and undergraduate students and some group management. The post holder will be required to work flexibly to, i) conduct descriptive and mechanistic human immunology assays for immunoepdemiology studies of infectious and non-infectious diseases, ii) conduct molecular assays to support the immunology studies and, iii) contribute to fieldwork through preparation of consumables shipments and proposals and where necessary, take part in fieldwork in Zimbabwe and other African countries.

The post holder will have a PhD (or soon to be completed) in immunology with a strong background in molecular biology or statistics. This is a full-time post for up to 12 months.

Institution/Organisation:
University of Edinburgh
Application deadline:
Postdoctoral Scientist - Cancer Immunology

A Postdoctoral Scientist position is available in Dr Jan Rehwinkel’s group in the MRC Human Immunology Unit in Oxford. You will play a key role in studies dissecting the role of the innate immune system in cancer. The group investigates how nucleic acids that are produced during infection with a variety of viral pathogens or in autoinflammatory diseases and cancer trigger immune receptors, focussing on innate sensors that survey the cytoplasm.

The project will follow on from our interest in SAMHD1. This interesting protein plays roles in virus infection, autoimmunity and cancer, and the latter will be dissected in this project. This work will involve in vivo models, as well as in vitro techniques including genome editing, molecular biology and cell culture. This work will be funded by the CRUK-LifeArc-Ono Immunooncology Alliance.

It is essential hat applicants have a PhD or anticipate completing a PhD in the near future. You will need to demonstrate a flair for original research from your proven track record and previous experience in innate immunology, cancer, or a related area. Previous experience with in vivo cancer models is desirable. You will be required to display flexibility, commitment and a willingness to innovate, delivered via excellent communication skills. You must have the ability to work efficiently as part of a team as well as independently. Additionally, you will be prepared to take initiative to offer help and advice to colleagues and liaise effectively with the Group Leader

Institution/Organisation:
University of Oxford
Application deadline:
Professor of Vaccinology

The University of Surrey is an international university with an excellent teaching and research profile that is innovative, forward thinking and achieving notable results.  As a result of our new strategic plan and future vision, the School of Biosciences and Medicine in the Faculty of Health and Medical Sciences is recruiting an exceptional person to the following academic position to continue to add to the successes at School, Faculty and University level and to work closely with The Pirbright Institute.

This is a very exciting opportunity underpinned by a substantial philanthropic contribution and a partnership between the University and The Pirbright Institute.  The position will be within the Section of Immunology in the Department of Biochemical Sciences, part of the School of Biosciences and Medicine at the University.

This position will be a part of the Bill and Melinda Gates Foundation-funded Pirbright Livestock Antibody Hub. This hub will exploit the recent advances in our understanding of B-cell responses to better understand the protective immune response in livestock and poultry with a strong translational and one health focus. Ultimately the Hub will support rational vaccinology approaches, antibody-based treatment and prophylaxis as well as increasing the applicability of animals as models for human disease and treatment. This post represents part of our strategic development as a School to further cement existing close working relationships with The Pirbright Institute.

If you are a dynamic, forward-thinking team player with a ‘can do’ attitude and a desire to achieve personally then please get in touch.   You will be expected to evidence an outstanding track record of achievement in scholarship and research and have a clear strategy to attract and secure research funding.  You will also be required to contribute to teaching at both undergraduate and postgraduate levels.

Institution/Organisation:
University of Surrey
Application deadline:
Research Associate in Immunology and Extracellular Matrix Biology (ImmunoMatrix)

Recruitment of leukocytes from the circulation to underlying tissues is a fundamental process that is critical to development and fighting infection. However, when this process goes wrong it is central to inflammatory diseases such as rheumatoid arthritis as well as atherosclerosis and cancer. 

Chemokines are the key regulators of leukocyte recruitment; they are presented on the endothelial surface where they bind to their receptors on circulating leukocytes. Chemokine interactions with their receptors lead to signalling events that enable movement of leukocytes from the circulation through the endothelium and into underlying tissues. The chemokine system collaborates with the extracellular matrix to drive leukocyte recruitment, but we are yet to successfully target chemokines during inflammatory disease.

This project is focused on understanding how the glycocalyx, an extracellular matrix barrier that lines blood vessels, collaborates with chemokines to regulate leukocyte recruitment. Manchester have demonstrated that certain chemokines may function by directly modulating the glycocalyx barrier and not via the classical mechanism of signalling through chemokine receptors. They have also demonstrated that the biochemistry of the glycocalyx is tuned to produce interaction with, and localisation of, specific chemokines. This will build upon a series of recent papers demonstrating that the chemokine system is built upon specificity and not redundancy.

This project will utilise cutting edge multi-photon imaging in vivo to directly study the glycocalyx and dissect its role in regulating leukocyte recruitment at rest and during inflammation. A truly multi-disciplinary approach is taken within the newly established Dyer lab, incorporating biophysics, biochemistry and in vivo immunology. Ultimately this will lead to development of novel therapeutics to ameliorate inflammatory disease and cancer.

You will be responsible for driving forward an exciting and innovative package of work to directly image the glycocalyx and determine how it is regulated during inflammation to facilitate leukocyte recruitment. 

Successful candidates may be subject to pre-employment screening carried out on our behalf by a third party. The offer of employment will be dependent on the successful candidate passing that screening. Whilst you will be required to provide express consent at a later stage, by continuing with your application now you acknowledge that you are aware that such screening will take place, and agree to take part in the process.

Institution/Organisation:
University of Manchester
Application deadline:
Professor or Reader in Immunology

Hull York Medical School are now seeking an outstanding immunologist to join our Experimental Medicine and Biomedicine Group. This group is part of the York Biomedical Research Institute (YBRI) which is an Interdepartmental Research Institute created by the University of York and Hull York Medical School. Immunology, Haematology and Infection (IHI) is one of three themes within YBRI; research within this theme ranges from fundamental studies on immunology, haematology, microbiology and parasitology through to first-in-human and other early phase clinical research. The aim is to develop a greater understanding of the processes underlying chronic infectious and non-infectious disease, and thus to develop new approaches to prevention and treatment.

The IHI theme has evolved from the Centre for Immunology and Infection, which was established in 2004 and expanded into additional purpose-built accommodation in 2010. Within the current 2000m² of research and office space, there are excellent facilities for research on ACDP HG3 organisms and a Biological Services Facility (to CL3) is nearby. Proximity to the Biosciences Technology Facility ensures ready access to state of the art and well-supported cutting-edge technology platforms. The IHI theme has an increasing network of collaborators based in lower and middle-income countries with multiple projects supported by the UK’s Global Challenges Research Fund. Interdisciplinary research is at the heart of the IHI, with collaborations extending across multiple departments.

The successful candidate will be an established internationally-recognised, PhD qualified immunologist. They will have an established track record of publications and research grant income and will be working in any area of immunology that provides new or novel synergistic opportunities within and beyond IHI. The teaching of immunology is also an important remit of the IHI and the appointee will contribute to teaching on the School’s MB BS course and its joint courses with Biology: the BSc and MBiomedSci in Biomedical Sciences.

Institution/Organisation:
University of York
Application deadline:
Postdoctoral Researcher in Computational Genomics of Inflammation

The Nuffield department of Orthopaedics, Rheumatology and Musculoskeletal sciences are seeking a highly motivated, academically excellent and proactive postdoctoral researcher with a strong background in computational genomics to join the Genomics of Inflammation group of Professor Irina Udalova at the University of Oxford.

You will be carrying out research on the transcriptional and molecular control of pathogenic interactions between myeloid cells in inflammatory tissue microenvironment, within a leading-edge programme funded by the Wellcome Trust. The lab are using cutting edge single cell genomic and computational approaches, unique in vivo models and advanced immunological and imaging approaches. You will utilise multi-scale computational models to provide a knowledge constrained framework for quantitative analysis and interpretation of resulting experimental data. You will take responsibility for the planning and execution of high-quality research, contribute ideas for new research projects and test hypotheses and analyse scientific data from a variety of sources.

You will be based at the Kennedy Institute of Rheumatology, University of Oxford, which is a world-leading research centre where discovery research drives development of transformative therapies for chronic inflammatory and degenerative disease. You will benefit from intellectually stimulating vibrant international research environment and outstanding support, including high performance computational facility and established a Computational Biology research group.

You will hold a PhD (or near completion) in functional and computational genomics, or similar. You will have knowledge of various programming languages, bioinformatics and machine learning, to work within established research programmes. You will demonstrate capacity to deliver high quality research outputs, illustrated by a strong publication record in high profile scientific journals. Expertise in analysis of transcriptional and epigenetic control of innate immunity would be desirable.

This is a full-time appointment fixed-term for 2 years in the first instance, extendable to 3 years.

Institution/Organisation:
University of Oxford
Application deadline:

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