The Thaventhiran group, within the Medical Research Council Toxicology Unit (MRC-TU), is the Cancer Immunology group, that uses human and mouse models to determine the therapeutic window of immune checkpoint blockade. Their investigation of rare patients with monogenic causes of immune dysregulation has identified a number of genes that are immune checkpoints, since their loss-of function leads to adaptive immune cell activation(1-3).
Mechanistic studies are now underway that use a novel transgenic mouse that fate-maps antigen receptor signalling, which in combination with single cell RNAseq/CITEseq can define the clonal dysfunction caused by targetting of immune pathways. This model allows us to kinetically track individual B and T cell clonal responses to any trigger across multiple tissue sites.
They are now looking to appoint a postdoctoral Research Associate to join our team in an exciting research project that uses the above systems to investigate the contribution of self-reactive lymphocytes to disease. The post will be ideal for a trained murine immunologist who is seeking experience in computational biology. However, talented candidates with a strong background in statistical methods or computational biology who are keen to develop experience in immunology are very much encouraged to apply. Additionally, the post-holder will have the freedom to develop their own projects, in line with lab interests.
The MRC-TU is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including super resolution microscopy, advanced flow-cytometry and offers excellent opportunities for postdoctoral development. The Unit is currently located at Leicester and will physically relocate to the Gleeson Building, Cambridge in 2020. This post will initially be based at the CRUK-CI, Cambridge, prior to relocation to the Gleeson Building.
Applicants must hold, or be close to completing, a PhD in a relevant discipline such as Immunology or Computational Biology. The project will require significant time working with preclinical models of immune checkpoint loss, generating single-cell RNA sequencing datasets and the computational analysis of these. A PhD student will work alongside the post-holder and complement their skills, so, working as part of a team within the laboratory environment is an essential attribute. The ability to work both independently in relation to the candidates existing expertise, together with excellent communication and critical thinking skills are also essential.
Appointment at Research Associate is dependent on having a PhD. Where a PhD has yet to be awarded or submitted appointment will initially be made as a Research Assistant and amended to Research Associate when the PhD is awarded.