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Immunology's top 20

Immunology cover

As part of our 60th anniversary celebrations for Immunology, we present a collection of the 20 highest-cited papers from the journal’s archives.

This collection features work spanning the six decades since the journal was launched, and marks many important advances in immunology – from earlier work on developing techniques to differentiate lymphocytes or eliminate antigens, through to more recent advances on the role of inflammation in neurodegenerative diseases and signaling in immunometabolism.

All the papers in the collection are freely available to read.


Inflammation in neurodegenerative diseases

Amor S, Puentes F, Baker D, van der Valk P.

Immunology. 2010 Feb;129(2):154-69. doi: 10.1111/j.1365-2567.2009.03225.x.

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The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games

Hehlgans T, Pfeffer K.

Immunology. 2005 May;115(1):1-20.

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Signal transduction by the lipopolysaccharide receptor, Tolllike receptor4

E M Pålsson‐McDermott, and L A J O'Neill

Immunology. 2004 Oct; 113(2): 153–162.

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Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1

J G Damoiseaux, E A Döpp, W Calame, D Chao, G G MacPherson, and C D Dijkstra

Immunology. 1994 Sep; 83(1): 140–147.

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Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature

U O'Doherty, M Peng, S Gezelter, W J Swiggard, M Betjes, N Bhardwaj, and R M Steinman

Immunology. 1994 Jul; 82(3): 487–493.

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Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1

S H Smith, M H Brown, D Rowe, R E Callard, and P C Beverley

Immunology. 1986 May; 58(1): 63–70.

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The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3

C D Dijkstra, E A Döpp, P Joling, and G Kraal

Immunology. 1985 Mar; 54(3): 589–599.

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Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3

A P Robinson, T M White, and D W Mason

Immunology. 1986 Feb; 57(2): 239–247.

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The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues

A N Barclay

Immunology. 1981 Apr; 42(4): 593–600.

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Mucosal immunology

J. Bienenstock and A. D. Befus

Immunology. 1980 Oct; 41(2): 249–270.

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Effects of the new anti-lymphocytic peptide cyclosporin A in animals

J F Borel, C Feurer, C Magnée, and H Stähelin

Immunology. 1977 Jun; 32(6): 1017–1025.

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Infectious immunological tolerance

R. K. Gershon and K. Kondo

Immunology. 1971 Dec; 21(6): 903–914.

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Precipitin reactions of the C1q component of complement with aggregated γ-globulin and immune complexes in gel diffusion

V. Agnello, R. J. Winchester, and H. G. Kunkel

Immunology. 1970 Dec; 19(6): 909–919.

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Two distinct populations of peripheral lymphocytes in mice distinguishable by immunofluorescence

M. C. Raff

Immunology. 1970 Oct; 19(4): 637–650.

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Cell interactions in the induction of tolerance: the role of thymic lymphocytes

R. K. Gershon and K. Kondo

Immunology. 1970 May; 18(5): 723–737.

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Contact and delayed hypersensitivity in the mouse

I. Active sensitization and passive transfer

G. L. Asherson and W. Ptak

Immunology. 1968 Sep; 15(3): 405–416.

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Further improvements in the plaque technique for detecting single antibody-forming cells

A. J. Cunningham and A. Szenberg

Immunology. 1968 Apr; 14(4): 599–600.1.

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Quantitative assay of the lytic action of immune lymphoid cells of 51Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs

K. T. Brunner, J. Mauel, J.-C. Cerottini, and B. Chapuis

Immunology. 1968 Feb; 14(2): 181–196.

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Immunological studies of an atypical (myeloma) immunoglobulin

S. G. O. Johansson and H. Bennich

Immunology. 1967 Oct; 13(4): 381–394.

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Specific inhibition of antibody production IV: Standardization of the antigen-elimination test; immunological paralysis of mice previously immunized

Immunology. 1965 Sep; 9(3): 261–273.

D. W. Dresser

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Immunology has been supporting the work of the BSI since 1958. Profits derived from the sale of the journal are invested back into the BSI, providing major financial support for the Society's activities – including our travel grants, regional and affinity groups meetings, BSI Congress and more. Find out more about submitting to Immunology here: Call for Submissions.