Applications are invited for a Research Associate to work within Dr Cecilia Johansson in the Respiratory Infection Section of the National Heart & Lung Institute at Imperial College London. You will work on an exciting project funded by the MRC to study the generation and functionality of tissue-resident T cells during respiratory viral infections.
We are looking for an immunologist who is interested to explore what is regulating the generation, maintenance and functionality of lung resident T cells during viral infections such as respiratory syncytial virus (RSV) and influenza virus. This project will include transgenic and knockout mice models as well as precision cut lung slices from human lung tissue.
The purpose of the post is to find the optimal requirements for lung CD8+ Trm cells to be induced, harnessed and manipulated for generation of efficient memory responses to respiratory virus infections such as RSV and influenza.
Duties and responsibilities
You will develop and implement assays for studying immune responses especially the T cell responses in airways and lung from virus infected mice or human tissue slices, based on an existing strong ability in flow cytometry and microscopy.
Further duties will involve:
- Design, plan and perform experimental work and other research activities.
- Project management, supervision of students and technical staff.
- Maintain an accurate record of all experimental work, analyse data, write reports and publications as well as present the work on meetings and conferences.
- Be self-motivated, responsible, organised and efficiently manage time and experiments.
- To take initiatives in the planning of research
- To identify and develop suitable techniques, and apparatus, for the collection and analysis of data
- To plan and conduct experiments using animal models, flow cytometry and other techniques with appropriate supervision
- To conduct data analysis
- To ensure the validity and reliability of data at all times
- To maintain accurate, organised and complete records of all findings from experimental work
- Essential requirements
You will have, or have recently submitted, a PhD in Immunology or in a related discipline, with a strong experience in murine models and techniques such as flow cytometry and microscopy.
Also, being a conscientious team-player, supporting other scientists and students in the lab, providing training and support where necessary and contributing to the safety and upkeep of the laboratory is essential.