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Neuroimmunometabolic mechanisms that slim down fat



This webinar from our Regional & Affinity Group series is brought to you by the BSI Immunometabolism Affinity Group. This session will be presented by Professor Ana Domingos and will take place on Thursday 27 May from 15:00 to 15:45 BST. 

This webinar will explore the neuroimmune mechanisms that underlie obesity. Professor Domingos will introduce her laboratory's work exploring the nerve pathways for fat mass reduction and the immune cells involved in these mechanisms. She will discuss how these findings have inspired a new class of anti-obesity compounds.

Speaker: Professor Ana Domingos, Associate Professor of Neuroscience, Department of Physiology, Anatomy & Genetics at University of Oxford and Wellcome Trust International Research Scholar

The Domingos laboratory discovered neuro-adipose junctions between white adipocytes and sympathetic neurons that they demonstrated to be necessary and sufficient for fat mass reduction via norepinephrine (NE) signalling. Moreover, they discovered Sympathetic neuron-Associated Macrophages (SAMs) that import and metabolize NE. Abrogation of SAM function promotes long-term amelioration of obesity independently of food intake. These findings inspired the development of a new class of anti-obesity compounds named sympathofacilitators which do not enter the brain nor have the typical cardiovascular side effects of old centrally acting sympathomimetic drugs.

This webinar is free for all BSI members. Non-members will be charged £10. You can join the BSI online – membership provides many benefits to help you progress your career. Undergraduate membership is free.


The BSI Regional & Affinity Group webinar series is supported by Miltenyi Biotec.