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Research Associate [Maternity Cover]

The Halim lab is actively recruiting highly talented and motivated scientists to join a vibrant and collaborative tumour immunology group within the University of Cambridge, CRUK Cambridge Institute. We are interested in understanding the role of innate lymphoid cells in regulating the immune response to cancer. Our long-term goal is to pharmacologically modulate the function of innate lymphoid cells with an aim to polarize the local immune environment towards an anti-cancer phenotype.

The postdoctoral researcher will benefit from collaborating directly on several mature projects, which we aim to submit for publication during this period. Additionally, there are opportunities for independently working on emerging projects in the lab.

As a postdoctoral researcher in the group, you will drive research projects that utilize novel in vivo and in vitro models to assess the function of immune cells in cancer, as well as study signalling pathways and downstream mechanisms using cutting edge genomic and proteomics approaches. You will join a collaborative and highly motivated team of researchers in a top ranked university and research institute. Our group is further supported by world-leading core facilities which researchers are encouraged to utilize to their fullest potential.

Candidates should be proficient in most of these:

  • Mouse experimental procedures (existing UK PIL highly valued), tissue processing, isolation and phenotyping/manipulation of cells using:
  • Advanced flow cytometry (i.e. high-parameter panel design, troubleshooting, data analysis)
  • Immunological assays, IF microscopy, and cell culture
  • Molecular biological techniques (i.e. cloning, viral vector design/production, genome editing strategies)

Candidate should have experience and/or a strong understanding in:

  • Bioinformatic analysis (i.e. Experimental design of bulk or single cell transcriptomic experiments, generation of high quality datasets, independent or collaborative analysis of data)
  • Tumour biology/immunology (i.e. experience with mouse tumour models, or human patient material)

The following additional skills are highly valued:

  • High-parameter IF or mass-spec imaging, spatial transcriptomics
  • Immunometabolic experience (i.e. metabolomic profiling, Seahorse analysis)
  • Ideally you have demonstrated creative and independent work in your area of expertise

Applicants who wish to be considered must display the ability to undertake project management, method development, data collection and analysis. You must have excellent communication and organizational skills, the ability to develop innovative experimental approaches to answer research questions, and thrive both in independent research and while working collaboratively as part of a team.

The successful candidate must have (or be about to receive) a PhD in immunology.

University of Cambridge