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Checkpoint blockade – understanding mechanisms, unlocking new approaches

IET Birmingham: Austin Court, 80 Cambridge Street, Birmingham, West Midlands B1 2NP


The BSI Tumour Immunology Group are excited to celebrate the relaunch of this Affinity Group with an inaugural high quality one-day meeting on the 19 March 2020 at Austin Court Birmingham.

Immune checkpoint blockade has been making headlines for several years, transforming therapy for a range of previously untreatable advanced cancers. However, although some factors linked with improved responses are known, our understanding of the science underlying this approach is emphatically incomplete, and many patients do not respond to therapy, or experience serious side effects. The Tumour Immunology Group have worked hard to put together a strong programme (see below), focussing on exploring the fascinating and diverse immune axes that link with the checkpoint blockade concept.

In addition to providing a brief clinical perspective on current checkpoint blockade therapy, the range of speakers will explore the fundamental receptor-ligand systems involved in checkpoint blockade, key cellular subsets and regulatory axes, how the tumour and its microenvironment influence checkpoint blockade, followed by novel therapy developments in the checkpoint blockade area, including combination approaches and neoantigen reactive T cell therapy. The day will end with a networking session to bring together attendees from all stages of the therapeutic pathway, from basic scientists to translational clinicians and industry partners. 


Programme

09:30​ –​ 10:00​ Welcome refreshments

10:00 – 10:15 Introduction Gary Middleton (University of Birmingham)

First Session – Molecular Mechanisms of Checkpoint Blockade

10:15 – 10:45 Simon Davis (University of Oxford)

10:45 – 11:15 Jannie Borst (Leiden University)

11:15 – 11:45 Sergio Quezada (University College London)

Lunch 12:00 – 13:00

Second Session – Tumour Genetics and Microenvironment Influencing Checkpoint Blockade

13:00 – 13:30 Ping-Chih Ho (University of Lausanne)

13:30 – 14:00 Shoba Amarnath (University of Newcastle)

14:00 – 14:30 David Withers (University of Birmingham)

14:30 – 15:00 Nicholas McGranahan (University College London)

Break 15:00 – 15:30

Third Session – Novel Therapeutics and Combinations

15:30 – 16:00 Jane Robertson (Achilles Therapeutics)

16:00 – 16:30 Juliet Gray (University of Southampton)

16:30 – 17:00 Gary Middleton (University of Birmingham)

17:00​ – 16:30​ Finish and refreshments


Abstracts

Abstract submission will open soon.


Registration

Registration is now open. You can join the BSI online - membership provides many benefits to help you progress your career. Undergraduate membership is free. 

 BSI Members
 BSI Member - Full & Early Careers *  £30
 BSI Member - Postgraduate (including PhD, Masters)  £20
 BSI Member - Concessionary **  £20
 Non-Members
 Full & Early Careers *  £50
 Postgraduate (including PhD, Masters)  £35
 Concessionary **  £35
 Undergraduate (membership is free)  £10

*  Early careers includes scientists employed as post-doctoral researchers, for the first 5 years post graduation.
** Concessionary includes Parental leave, Career Breaks, Retired, Emeritus Retired.


Sponsors

If you are interested in sponsoring this event, please email Jane Sessenwein