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Multi-cellular differentiation-related changes in the immune system during ageing

Academy of Medical Sciences, Portland Place, London, UK
Thursday, 27 September, 2018 - 12:00 to Friday, 28 September, 2018 - 16:00


The British Society for Immunology's Lymphocyte Immunosenescence and Differentiation Group is pleased to bring you 'Multi-cellular differentiation-related changes in the immune system during ageing' taking place on 27-28 September 2018 at the Academy of Medical Sciences in London. 

Both innate and adaptive immunity change during ageing which leads to increased susceptibility to infection and malignancy and a decreased response to vaccination. At the same time altered immune homeostasis may lead to low-grade inflammation and chronic inflammatory conditions. This meeting will highlight changes in leukocyte types during differentiation and/or ageing, how they are integrated, and the impact of intrinsic (cellular-molecular) and extrinsic (physiological/ environmental) factors on immune alterations. We will also discuss strategies for intervention to boost immunity in older adults using evidence from animal and human models.


This meeting will bring together world leaders in cell differentiation and immunosenescence, including eight invited speakers.

Thursday 27 September 2018

13.00–13.50: Registration
13.50–14.00: Welcome

14.00–14.30: Senescent B cells: impact on the regulation of protective and autoreactive antibody responses in the elderly​ 
Dr Daniela Frasca , University of Miami, USA    

14.30–15.00: Differential susceptibility to cellular aging in the T cell family
Dr Anis Larbi, A* Institute Singapore

15.00–15.15: Faecal microbiota transplantation restores the reduced germinal centre response in Peyer’s patches of aged mice
Marisa Stebegg, Babraham Institute, UK

15.15–15.30: T and B Lymphocyte Senescence in Parkinson’s Disease
Melanie Jenson, University of Cambridge, UK

15.30–16.00: Break

16.00– 16.30: Aberrant migration of senescent T cells​ 
Dr Siân Henson, Queen Mary's University of London, UK    

16.30–16.45: A mouse model of respiratory viral infection in the elderly
Sophie Saqawe, Imperial College London, UK

16.45–17.45: Immune senescence: causes and corrections
Prof Janet Lord, University of Birmingham, UK               

17.45–19:00: Networking and drinks

Friday 28 September

09.30–10.00: Coffee
10.00–10.10: Welcome

10.10– 11.00: The metabolic signature of pro-inflammatory T cells 
Prof Cornelia Weyand, Stanford University, USA      

11.00–11.30: Immune surveillance of senescent cells: mechanisms and implications for aging​
Dr Valery Krizhanovsky, Weizmann Institute of Science, Israel

11.30–11.45: Metabolic mimicry of high-intensity exercise prevents apoptosis of memory T cells during sepsis
Jenifer Sanchez, Queen Mary University of London, UK

11.45–12.00: CMV and senescent T cells: red herring or black sheep?
Florian Kern, Brighton and Sussex Medical School, UK

12.00–12.15: Phenotyping senescent T/B cells using REAffinity Antibodies 
Claire Wiseman, Miltenyi Biotec​

12.15 – 13.45: Networking and lunch

13.45 – 14.15: Aged monocytes/macrophages in the immunopathology of Giant Cell Arteritis
Prof Mieke Boots, University of Groningen, Netherlands

14.15 – 14.30: Zebrafish leukocytes have telomerase-dependent hyper-long telomeres and gut-macrophages require telomerase for efficient phagocytosis
Catarina Henriques, University of Sheffield, UK

14.30 – 14.45: Aged insulin resistant macrophages display profound transcriptome changes in inflammatory gene expression
Matthew C. Gage, University College London, UK

14.45 – 15.00: Sestrins induce natural killer function in senescent CD8+ T cells
Roel De Maeyer, University College London , UK

15.00 – 15.15: Human ageing is associated with reduced natural killer cell cytoxicity against and migration towards senescent cells
Jon Hazeldine, University of Birmingham, UK

15.15 – 15.45: Enhancing immunity during ageing
Prof Arne Akbar, University College London, UK  

15.45: Closing remarks


Online registration is now open. You can join the BSI online - membership provides many benefits to help you progress your career. Undergraduate membership is free. 


 BSI Members
 BSI Member - Full  £70
 BSI Member - Early Careers *  £70
 BSI Member - Postgraduate (including PhD, Masters)  £40
 BSI Member - Concessionary **  £40
 Non-Member  £150
 Non-Member - Postgraduate (including PhD, Masters) & Concessionary  £70
 Undergraduates  £20

*  Early career members include scientists employed as post-doctoral researchers, for the first 5 years post graduation.
** Concessionary includes Parental leave, Career Breaks, Retired, Emeritus Retired.


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