Today, The Nobel Assembly at Karolinska Institutet announced that they have awarded the 2025 Nobel Prize in Physiology or Medicine to Mary E. Brunkow, Institute for Systems Biology, USA, Fred Ramsdell, Sonoma Biotherapeutics, San Francisco, USA and Shimon Sakaguchi, Osaka University, Japan. They were selected “for their discoveries concerning peripheral immune tolerance.”
In response, the BSI has released the following statement.
Professor Tracy Hussell, President, British Society for Immunology, said:
“We’re delighted to see that once again immunologists are recognised in this year’s Nobel Prize in Physiology or Medicine. Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi’s research into the discovery and function of regulatory T cells has been fundamental in understanding how the immune system is regulated to prevent bystander tissue damage.
“By building our knowledge of the role that regulatory T cells play in preventing the immune system from attacking the body’s own cells, the winners’ discoveries have unlocked new avenues for the development of treatments (and even potentially cures) for autoimmune diseases. They have also laid the foundations for developing better cancer treatments and improved tolerance in people receiving organ transplants.
“On behalf of the immunology community, I would like to extend our warm congratulations to Mary, Fred and Shimon for their well-deserved recognition.”
The 2025 Nobel Prize Virtual Issue
We have collected papers on peripheral immune tolerance from all three of the BSI’s journals, Immunotherapy Advances, Clinical & Experimental Immunology and Discovery Immunology. We are proud to be able to contribute to such a vital part of immunology research.