We are living through a renaissance in metabolism research, which touches many fields of basic research and clinical medicine. Immunometabolism and cancer metabolism have been at the forefront of these studies since the early 2000s. After over a decade of research in the field of immunometabolism, which has deepened our understanding of the basic processes which intertwine metabolic to signalling pathways in the control of adaptive and innate immunity, the time is right to translate these discoveries to the clinical settings.
We are pleased to present the latest Review Series from Clinical & Experimental Immunology, ‘Translating Immunometabolism’.
For this series, editors Sarah Dimeloe and Claudio Mauro have commissioned review articles covering aspects of translational immunometabolism research, touching on inflammation, autoimmunity and cancer.
Editorial by Sarah Dimeloe and Claudio Mauro:
Translating immunometabolism: towards curing human diseases by targeting metabolic processes underpinning the immune response
S. Dimeloe and C. Mauro
Clin Exp Immunol. doi.org/10.1111/cei.13347
Sculpting tumour microenvironment with immune system: from immunometabolism to immunoediting
Y-R. Yu and P-C. Ho (2019)
Clin Exp Immunol. doi.org/10.1111/cei.13293
Sensing between reactions: how the metabolic microenvironment shapes immunity
J. Lötscher and M. L. Balmer (2019)
Clin Exp Immunol. doi.org/10.1111/cei.13291
Altered metabolic pathways regulate synovial inflammation in rheumatoid arthritis
U. Fearon, M. M. Hanlon, S. M. Wade and J. M. Fletcher (2019)
Clin Exp Immunol. doi:10.1111/cei.13228
Metabolism at the centre of the host-microbe relationship
K. M. Maslowski
Clin Exp Immunol. doi.org/10.1111/cei.13329
Original Research: Underpinning ‘Translating Immunometabolism’
Type 2 diabetes is associated with the accumulation of senescent T cells
E. Y. M. Lau, E. C. Carroll L. A. Callender, G. A. Hood, V. Berryman, M. Pattrick S. Finer, G. A. Hitman, G. L. Ackland and S. M. Henson
Clin Exp Immunol. doi.org/10.1111/cei.13344
Other Clinical & Experimental Immunology Review Series
Check out our other Review Series on topics such as 'Regulatory T cells: exploring mechanisms for future therapies' and 'Vaccines for Emerging Pathogens: from Research to the Clinic'.