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World Arthritis Day 2018: New Virtual Issue

World Arthritis Day

To mark World Arthritis Day 2018, Clinical & Experimental Immunology presents a new virtual issue of selected articles from the journal.

‘Arthritis’ refers to a broad group of disorders which affect the joints of the body. The papers in this collection largely focus on rheumatic forms of arthritis, which are characterised by chronic inflammation and a build-up of synovial tissue and fluid in the joints, which can ultimately result in the destruction of bone and cartilage.

The collection features some of the recent key reviews and primary research papers on arthritis published in our journal. It includes work on cytokines and other immune mediators produced in the inflamed joints, antibody modification, the contribution of stromal cells and myeloid cells in joint inflammation, the genetics of arthritis, and recent insights into immune modulation and intervention of arthritis.

All the articles in this collection have been published in issues of the journal from 2016 to 2018. We hope you will enjoy this collection.


Immunogenetics/genetic regulation in arthritis

The rheumatic disease‐associated FAM167ABLK locus encodes DIORA‐1, a novel disordered protein expressed highly in bronchial epithelium and alveolar macrophages

Mentlein, L., Thorlacius, G. E., Meneghel, L., Aqrawi, L. A., Ramírez Sepúlveda, J. I., Grunewald, J., Espinosa, A. and Wahren‐Herlenius, M. (2018)

Clin Exp Immunol, 193: 167-177. doi:10.1111/cei.13138

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Polymorphisms in STAT‐4, IL‐10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis

Ciccacci, C., Conigliaro, P., Perricone, C., Rufini, S., Triggianese, P., Politi, C., Novelli, G., Perricone, R. and Borgiani, P. (2016)

Clin Exp Immunol, 186: 157-163. doi:10.1111/cei.12831

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Immunopathogenesis of systemic lupus erythematosus and rheumatoid arthritis: the role of aberrant expression of non‐coding RNAs in T cells

Lai, N., Koo, M., Yu, C. and Lu, M. (2017)

Clin Exp Immunol, 187: 327-336. doi:10.1111/cei.12903

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Genetics of immune‐mediated inflammatory diseases

David, T., Ling, S. F. and Barton, A. (2018)

Clin Exp Immunol, 193: 3-12. doi:10.1111/cei.13101

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Myeloid cell biology

Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells

Alivernini, S., Tolusso, B., Ferraccioli, G., Gremese, E., Kurowska‐Stolarska, M. and McInnes, I. B. (2018)

Clin Exp Immunol, 193: 13-23. doi:10.1111/cei.13098

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Characteristic elevation of soluble TNF receptor II : I ratio in macrophage activation syndrome with systemic juvenile idiopathic arthritis.

Shimizu, M., Inoue, N., Mizuta, M., Nakagishi, Y. and Yachie, A. (2018)

Clin Exp Immunol, 191: 349-355. doi:10.1111/cei.13026

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Stromal cells

TXNDC5 contributes to rheumatoid arthritis by down‐regulating IGFBP1 expression

Li, J., Xu, B., Wu, C., Yan, X., Zhang, L. and Chang, X. (2018)

Clin Exp Immunol, 192: 82-94. doi:10.1111/cei.13080

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Rheumatoid arthritis fibroblast‐like synoviocytes co‐cultured with PBMC increased peripheral CD4+CXCR5+ICOS+ T cell numbers

Tang, Y., Wang, B., Sun, X., Li, H., Ouyang, X., Wei, J., Dai, B., Zhang, Y. and Li, X. (2017)

Clin Exp Immunol, 190: 384-393. doi:10.1111/cei.13025

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The role of stromal cells in inflammatory bone loss

Wehmeyer, C., Pap, T., Buckley, C. D. and Naylor, A. J. (2017)

Clin Exp Immunol, 189: 1-11. doi:10.1111/cei.12979

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Antibody modification

Altered glycan accessibility on native immunoglobulin G complexes in early rheumatoid arthritis and its changes during therapy

Stümer, J., Biermann, M. H., Knopf, J., Magorivska, I., Kastbom, A., Svärd, A., Janko, C., Bilyy, R., Schett, G., Sjöwall, C., Herrmann, M. and Muñoz, L. E. (2017)

Clin Exp Immunol, 189: 372-382. doi:10.1111/cei.12987

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Immunoglobulin (Ig)G1 and IgG4 anti‐cyclic citrullinated peptide (CCP) associate with shared epitope, whereas IgG2 anti‐CCP associates with smoking in patients with recent‐onset rheumatoid arthritis (the Swedish TIRA project)

Martinsson, K., Johansson, A., Kastbom, A. and Skogh, T. (2017)

Clin Exp Immunol, 188: 53-62. doi:10.1111/cei.12901

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Effects of type II collagen epitope carbamylation and citrullination in human leucocyte antigen (HLA)‐DR4+ monozygotic twins discordant for rheumatoid arthritis

De Santis, M., Ceribelli, A., Cavaciocchi, F., Generali, E., Massarotti, M., Isailovic, N., Crotti, C., Scherer, H. U., Montecucco, C. and Selmi, C. (2016)

Clin Exp Immunol, 185: 309-319. doi:10.1111/cei.12825

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Cytokines/soluble mediators

Increased interleukin (IL)‐20 and IL‐24 target osteoblasts and synovial monocytes in spondyloarthritis

Kragstrup, T. W., Andersen, M. N., Schiøttz‐Christensen, B., Jurik, A. G., Hvid, M. and Deleuran, B. (2017)

Clin Exp Immunol, 189: 342-351. doi:10.1111/cei.12973

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Recombinant Salmonella typhimuriumouter membrane protein A is recognized by synovial fluid CD8 cells and stimulates synovial fluid mononuclear cells to produce interleukin (IL)‐17/IL‐23 in patients with reactive arthritis and undifferentiated spondyloarthropathy

Chaurasia, S., Shasany, A. K., Aggarwal, A. and Misra, R. (2016)

Clin Exp Immunol, 185: 210-218. doi:10.1111/cei.12799

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IL‐27: a double agent in the IL‐6 family

Jones, G. W., Hill, D. G., Cardus, A. and Jones, S. A. (2018)

Clin Exp Immunol, 193: 37-46. doi:10.1111/cei.13116

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The role of interleukin‐6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis

Schinnerling, K., Aguillón, J. C., Catalán, D. and Soto, L. (2017)

Clin Exp Immunol, 189: 12-20. doi:10.1111/cei.12966

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Interleukin (IL)‐9/IL‐9R axis drives γδ T cells activation in psoriatic arthritis patients

Guggino, G., Ciccia, F., Di Liberto, D., Lo Pizzo, M., Ruscitti, P., Cipriani, P., Ferrante, A., Sireci, G., Dieli, F., Fourniè, J. J., Giacomelli, R. and Triolo, G. (2016)

Clin Exp Immunol, 186: 277-283. doi:10.1111/cei.12853

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Interleukin‐9 and T helper type 9 cells in rheumatic diseases

Ciccia, F., Guggino, G., Ferrante, A., Cipriani, P., Giacomelli, R. and Triolo, G. (2016)

Clin Exp Immunol, 185: 125-132. doi:10.1111/cei.12807

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Immune modulation/intervention

The anti‐CD6 antibody itolizumab provides clinical benefit without lymphopenia in rheumatoid arthritis patients: results from a 6‐month, open‐label Phase I clinical trial

Rodríguez, P. C., Prada, D. M., Moreno, E., Aira, L. E., Molinero, C., López, A. M., Gómez, J. A., Hernández, I. M., Martínez, J. P., Reyes, Y., Milera, J. M., Hernández, M. V., Torres, R., Avila, Y., Barrese, Y., Viada, C., Montero, E. and Hernández, P. (2018)

Clin Exp Immunol, 191: 229-239. doi:10.1111/cei.13061

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Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4+ T cells partly via transforming growth factor‐β1

Anderson, A. E., Swan, D. J., Wong, O. Y., Buck, M., Eltherington, O., Harry, R. A., Patterson, A. M., Pratt, A. G., Reynolds, G., Doran, J., Kirby, J. A., Isaacs, J. D. and Hilkens, C. M. (2017)

Clin Exp Immunol, 187: 113-123. doi:10.1111/cei.12870

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Inflammatory cytokines compromise programmed cell death‐1 (PD‐1)‐mediated T cell suppression in inflammatory arthritis through up‐regulation of soluble PD‐1

Bommarito, D., Hall, C., Taams, L. S. and Corrigall, V. M. (2017)

 Clin Exp Immunol, 188: 455-466. doi:10.1111/cei.12949

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Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen‐induced arthritis Willis, V. C., Banda, N. K., Cordova, K. N., Chandra, P. E., Robinson, W. H., Cooper, D. C., Lugo, D., Mehta, G., Taylor, S., Tak, P. P., Prinjha, R. K., Lewis, H. D. and Holers, V. M. (2017)

Clin Exp Immunol, 188: 263-274. doi:10.1111/cei.12932

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Modulation of autoimmune arthritis severity in mice by apolipoprotein E (ApoE) and cholesterol

Alvarez, P., Genre, F., Iglesias, M., Augustin, J. J., Tamayo, E., Escolà‐Gil, J. C., Lavín, B., Blanco‐Vaca, F., Merino, R. and Merino, J. (2016)

Clin Exp Immunol, 186: 292-303. doi:10.1111/cei.12857

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Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice

Yamakawa, M., Ouhara, K., Kajiya, M., Munenaga, S., Kittaka, M., Yamasaki, S., Takeda, K., Takeshita, K., Mizuno, N., Fujita, T., Sugiyama, E. and Kurihara, H. (2016)

Clin Exp Immunol, 186: 177-189. doi:10.1111/cei.12847

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Gut microbiome in children with enthesitis‐related arthritis in a developing country and the effect of probiotic administration

Aggarwal, A., Sarangi, A. N., Gaur, P., Shukla, A. and Aggarwal, R. (2017)

Clin Exp Immunol, 187: 480-489. doi:10.1111/cei.12900

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Effect of probiotics on clinical and immune parameters in enthesitis‐related arthritis category of juvenile idiopathic arthritis

Shukla, A., Gaur, P. and Aggarwal, A. (2016)

Clin Exp Immunol, 185: 301-308. doi:10.1111/cei.12818

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The impact of disease activity and tumour necrosis factor‐α inhibitor therapy on cytokine levels in juvenile idiopathic arthritis

Walters, H. M., Pan, N., Lehman, T. J., Adams, A., Kalliolias, G. D., Zhu, Y. S., Santiago, F., Nguyen, J., Sitaras, L., Cunningham‐Rundles, S., Walsh, T. J. and Toussi, S. S. (2016)

Clin Exp Immunol, 184: 308-317. doi:10.1111/cei.12782

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