T cell targeted approaches in cancer immunotherapy

Special Collection Editor: Dr Adriana Bonomo, Oswaldo Cruz Foundation (FIOCRUZ), Brazil

Immunotherapy Advances features ongoing special collections on high-interest topics in immunotherapy throughout the year. This collection entitled ‘T cell-targeted approaches to cancer immunotherapy’ is led by Immunotherapy Advances’ Regional Editor for South America, Dr Adriana Bonomo, from FIOCANCER, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.

 Combination of genetically engineered T cells and immune checkpoint blockade for the treatment of cancer
 Combination of genetically engineered T cells and immune checkpoint blockade for the treatment of cancer

Articles in collection

Review

Seven mysteries of LAG-3: a multi-faceted immune receptor of increasing complexity

Stephanie E A Burnell, Lorenzo Capitani, Bruce J MacLachlan, Georgina H Mason, Awen M Gallimore, Andrew Godkin

​Review

Combination of genetically engineered T cells and immune checkpoint blockade for the treatment of cancer

Rafaela Rossetti, Heloísa Brand, Sarah Caroline Gomes Lima, Izadora Peter Furtado, Roberta Maraninchi Silveira, Daianne Maciely Carvalho Fantacini, Dimas Tadeu Covas, Lucas Eduardo Botelho de Souza

Review

Engineering CAR-NK cells: how to tune innate killer cells for cancer immunotherapy 

Dayane Schmidt, Sima Ebrahimabadi, Kauan Ribeiro de Sena Gomes, Graziela de Moura Aguiar, Mariane Cariati Tirapelle, Renata Nacasaki Silvestre, Júlia Teixeira Cottas de Azevedo, Dimas Tadeu Covas, Virginia Picanço-Castro

T Cell Target Approaches to Cancer
Figure from: Engineering CAR-NK cells: how to tune innate killer cells for cancer immunotherapy

Review

Peripheral blood persistence and expansion of transferred non-genetically modified Natural Killer cells might not be necessary for clinical activity 

Lucia Silla

Review 

Balancing the good and the bad: controlling immune related adverse events versus anti-tumor responses in cancer patients treated with immune checkpoint inhibitors 

Guilherme Ferreira de Britto Evangelista, Amanda Braga Figueiredo, Milton José de Barros e Silva, Kenneth J Gollob

Research Article 

Safety of the use of gold nanoparticles conjugated with proinsulin peptide and administered by hollow microneedles as an immunotherapy in type 1 diabetes

D Tatovic, M A McAteer, J Barry, A Barrientos, K Rodríguez Terradillos, I Perera, E Kochba, Y Levin, M Dul, S A Coulman, J C Birchall, C von Ruhland, A Howell, R Stenson, M Alhadj Ali, S D Luzio, G Dunseath, W Y Cheung, G Holland, K May, J R Ingram, M M U Chowdhury, F S Wong, R Casas, C Dayan, J Ludvigsson

Review

Obesity and adipose tissue impact on T-cell response and cancer immune checkpoint blockade therapy 

Gabriel Pasquarelli-do-Nascimento, Sabrina Azevedo Machado, Juliana Maria Andrade de Carvalho, Kelly Grace Magalhães