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COVID-19 Special Issue

Since the beginning of the COVID-19 pandemic, SARS-CoV-2 has infected tens of millions of people worldwide, with diverse clinical outcomes. During this time, immunologists and the wider scientific community have been working hard to uncover the molecular mechanisms that underlie its pathogenesis, while searching for effective treatment and vaccines. After nearly a year of researching SARS-CoV-2, it is time to consider the developments and persistent limitations, in our understanding of this pathogen.

In this special issue, Clinical & Experimental Immunology presents a collection of articles on crucial aspects of COVID-19, including original research, reviews and an editorial from Ryan Thwaites (Imperial College London). These papers discuss a variety of topics, including the role of innate immune system in progression of COVID-19, and possible routes to limit severity using immunomodulatory agents.

We present new findings about the antibody response to SARS-CoV-2, relevant for public health serosurveillance, and a thorough summary of vaccine approaches in development and in clinical trial globally.

We invite you to read the freely accessible papers and their accompanying summaries below, and encourage you to share this essential research on social media. Make sure to tag us @CEIjournal.


A year in our understanding of COVID‐19
R.S. Thwaites

Figure from Innate immunity during SARS‐CoV‐2: evasion strategies and activation trigger hypoxia and vascular damage


COVID-19 vaccine-readiness for anti-CD20-depleting therapy in autoimmune diseases
D. Baker, C.A.K. Roberts, G. Pryce, A.S. Kang, M. Marta, S. Reyes, K. Schmierer, G. Giovannoni, S. Amor
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Vaccines for COVID-19
J.S. Tregoning, E.S. Brown, H.M. Cheeseman, K.E. Flight, S.L. Higham, N.‐M. Lemm, B.F. Pierce, D.C. Stirling, Z. Wang, K.M. Pollock
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Innate immunity during SARS-CoV-2: evasion strategies and activation trigger hypoxia and vascular damage
S. Amor, L. Fernández Blanco, D. Baker
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Original research

Characteristics and roles of SARS-CoV-2 specific antibodies in patients with different severities of COVID-19
Z. Huang, H. Chen, M. Xue, H. Huang, P. Zheng, W. Luo, X. Liang, B. Sun, N. Zhong
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Factors determining COVID-19 pneumonia severity in a country with routine BCG vaccination
K. Aksu, T. Naziroğlu, P. Özkan
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Clinical & Experimental Immunology is an official journal of the British Society for Immunology. Profits derived from the sale of the journal are invested back into the BSI, providing major financial support for the Society's activities. Support the BSI by submitting your work!