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International Day of Immunology Virtual Issue: Autoimmunity and Autoinflammation

The current COVID-19 pandemic highlights how it is more relevant than ever to increase global awareness of immunology research in the fight against infection, autoimmunity and cancer.

Figure from Autoinflammatory disease in the lung
Figure from Autoinflammatory disease in the lung

In celebration of the International Day of Immunology on 29 April, we have compiled a selection of some of our favourite articles from Clinical & Experimental Immunology and Immunology to highlight this year’s theme: autoimmunity and autoinflammation.

Autoimmunity is a process by which the immune response reacts against its own healthy cells and tissues. This occurs when T and/or B cells, which are part of the adaptive or acquired immune response, inadvertently recognise self-antigens and subsequently drive a chronic inflammatory process that disrupts normal tissue function in a target organ.

Whilst there are some similarities between autoimmune and autoinflammatory disorders, autoinflammation is generally characterised by activation of innate, rather than adaptive, immune cells, leading to dysregulation of crucial pro-inflammatory cytokine pathways, thereby causing damage to host tissues. Autoinflammatory disorders are typically genetic conditions, whereas the triggers for autoimmune reactions are generally multifactorial.

This collection features some recent reviews and original research papers on the mechanisms underlying  autoinflammation and autoimmunity, and how autoinflammation and/or autoimmunity can contribute to arthritis, psoriasis, colitis, lung diseases and CNS neurodegenerative disorders like multiple sclerosis.

We hope you enjoy reading this collection of articles and that you will celebrate all immunology research on this International Day of Immunology and encourage you to share this using the hashtag #DoImmuno and looping in @CEIjournal and @immjournal.


Figure from 'NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis'
Figure from NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis

Clinical & Experimental Immunology

Evidence for a role of autoinflammation in early‐phase psoriasis
D. Fanoni, L. Venegoni, B. Vergani, S. Tavecchio, A. Cattaneo, B.E. Leone, E. Berti, A.V. Marzano.

A single administration of human adipose tissue‐derived mesenchymal stromal cells (MSC) induces durable and sustained long‐term regulation of inflammatory response in experimental colitis
V. B. Freitas Alves,  B. Coutinho de Sousa,  M. Thaís Costa Fonseca.

The role of FOXP3+ regulatory T cells in human autoimmune and inflammatory diseases
A Mohr M. Atif  R. Balderas  G. Gorochov  & M. Miyara.

The microbiome in autoimmune diseases
F. De Luca,  Y. Shoenfeld.

Immune cell metabolism in autoimmunity
X. Teng,  W. Li,  C. Cornaby,  L. Morel.

NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis
C. Guo,  R. Fu,  S. Wang,  Y. Huang,  X. Li,  M. Zhou,  J. Zhao,  N. Yang.



Figure from Inflammation in CNS neurodegenerative diseases

Autoinflammatory disease in the lung
T Scambler, J Holbrook, S Savic,  MF McDermott, D Peckham.

Metabolic regulation of inflammasomes in inflammation
Q Yang, R Liu, Q Yu, Y Bi, G Liu.

Autoimmunity and autoimmune co‐morbidities in psoriasis
K Furue, T Ito, G Tsuji, T Kadono, T Nakahara & M Furue.

Regulatory T cells control epitope spreading in autoimmune arthritis independent of cytotoxic T‐lymphocyte antigen‐4
M Yang, K Klocke, CM Hernandez, B Xu, I Gjertsson, K Wing, Rikard Holmdahl.

Inflammation in CNS neurodegenerative diseases
J Stephenson, E Nutma, P van der Valk & S Amor.

The Autoimmune Regulator (Aire) transactivates HLA‐G gene expression in thymic epithelial cells
BL Melo‐Lima, I Poras, GA Passos, ED Carosella, EA Donadi, P Moreau.

Clinical & Experimental Immunology is an official journal of the British Society for Immunology. Profits derived from the sale of the journals are invested back into the BSI, providing major financial support for the Society's activities. 

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