Microbiome: A joint virtual issue from the BSI and the Microbiology Society
To celebrate World Microbiome Day 2018 on 27th June, the British Society for Immunology and the Microbiology Society are pleased to present a joint Virtual Issue on the microbiome.
Immunology and Clinical & Experimental Immunology have long been at the forefront of journals offering a platform to immunologists seeking to narrate the exciting, evolving narrative of the interplay between microbiota-health or dysbiosis, immune subsets, inflammation and disease. The papers assembled for this collection offer a state-of-the art appraisal from many of the leading immunologists who have been working in this area. The wide array of pathologies discussed in this set – from autoimmune and inflammatory disease to bacterial sepsis, parasitic infection and obesity – offer a window onto the importance of microbiota for shaping the immune programme.
The aim of this set has been to offer a tour through current trends and passions in the field. Papers on Prevotella, segmented filamentous bacteria and other microbiota species set the scene, reminding us that immunologists still have much work ahead in defining the rules of how our thousand-plus passengers interact with immune receptors. Part of the new toolbox that has had to develop alongside this is the analysis of bacterial metabolites and their impacts on immune and inflammatory function.
Several studies in this collection describe detailed aspects of the interaction between diet, microbiota, immune subset differentiation, bacterial metabolites and disease. This will be a really important area to populate (funders – please take note!), with potentially enormous rewards. Immunology’s many outstanding contributions to modern biomedicine, including monoclonal antibody therapies, cancer checkpoint blockade and CAR T cells, have shared the property of being very challenging to healthcare economics. The promised revolution from greater understanding and manipulation of the microbiota-immune system axis offers the potential for our next great contribution, with many of the solutions affordable and accessible.
Alongside a jointly-published editorial by Professor Julian Marchesi outlining the need for greater collaboration between all subdisciplines in the field of microbiome research, we present articles from across the Societies’ collections and a video from the Editor-in-Chief of Immunology, Professor Daniel Altmann.
All articles in this collection are free to view online.
The role of gut microbiome and associated metabolome in the regulation of neuroinflammation in multiple sclerosis and its implications in attenuating chronic inflammation in other inflammatory and autoimmune disorders
Nicholas Dopkins, Prakash S. Nagarkatti, Mitzi Nagarkatti
Impact of stress on the gut microbiome of free-ranging western lowland gorillas
Klára Vlčková, Kathryn Shutt-Phillips, Michael Heistermann, Barbora Pafčo, Klára J. Petrželková, Angelique Todd, David Modrý, Karen E. Nelson, Brenda A. Wilson, Rebecca M. Stumpf, Bryan A. White, Steven R. Leigh, Andres Gomez
Differences in vaginal microbiome in African American women versus women of European ancestry
Jennifer M. Fettweis, J. Paul Brooks, Myrna G. Serrano, Nihar U. Sheth, Philippe H. Girerd, David J. Edwards, Jerome F. Strauss III, the Vaginal Microbiome Consortium, Kimberly K. Jefferson, Gregory A. Buck