To mark Rheumatoid Arthritis Awareness Week 2020, Clinical & Experimental Immunology presents a new virtual issue highlighting some of the cutting edge research and reviews covering all aspects of rheumatoid arthritis. Scroll down to discover the 15 excellent articles selected for this collection!
What is rheumatoid arthritis?
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by self-sustaining inflammation of the synovial tissues of the joints. Although the aetiology of the disease is unknown, there are a number of environmental and genetic risk factors associated with disease incidence and severity, including smoking, obesity, vitamin D deficiency and HLA type. As an autoimmune disease, RA is the result of an immune response in which the body’s immune system attacks its own healthy cells. Once the disease is triggered, immune cells migrate into the joints where they produce signals leading to the activation and recruitment of more immune cells, which in turn impact on synovial fibroblasts which perpetuate inflammation of the synovium and are responsible for the progressive destruction of cartilage and bone tissue.
Despite the impressive progress made in recent decades in gathering information on the pathogenesis and in the availability of therapeutic tools, our understanding of the mechanisms underlying the chronicity of rheumatoid arthritis and the heterogeneity in the disease manifestations and in the patient responses to treatments remains limited.
Discover our collection and get involved
Our collection features some recent reviews and primary research papers from the past few years, covering the areas that appear most promising in this hot topic, from the role of the interaction between dendritic cells, T cells and other myeloid cells with each other and with recruited fibroblasts and bone cells; the unexpected role of metabolic pathways and of inflammasomes, activated systemically and in the synovial microenvironment; to the identification of biomarkers that can help dissect the clinical and molecular heterogeneity of rheumatoid arthritis.
Join us in raising awareness about rheumatoid arthritis on this RA Awareness Week by sharing research about the immunology of the disease with the hashtag #RAAwarenessWeek and Twitter handle @CEIjournal.
We hope you enjoy reading this collection of articles, all free to access for this virtual issue.
Dendritic cells, T cells and their interaction in rheumatoid arthritis
P. Wehr, H. Purvis, S.‐C. Law, R. Thomas
Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells
S. Alivernini, B. Tolusso, G. Ferraccioli, E. Gremese, M. Kurowska‐Stolarska, I. B. McInnes
NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis
C. Guo, R. Fu, S. Wang, Y. Huang, X. Li, M. Zhou, J. Zhao, N. Yang
Blocking of YY1 reduce neutrophil infiltration by inhibiting IL‐8 production via the PI3K‐Akt‐mTOR signaling pathway in rheumatoid arthritis
J. Lin, Y. He, B. Wang, Z. Xun, S. Chen, Z. Zeng, Q. Ou
Immune‐bone interplay in the structural damage in rheumatoid arthritis
N. Komatsu, H. Takayanagi
Rheumatoid arthritis synovial microenvironment induces metabolic and functional adaptations in dendritic cells
M. Canavan, V. Marzaioli, T. McGarry, V. Bhargava, S. Nagpal, D. J. Veale, U. Fearon
Neutrophil proteases degrade autoepitopes of NET‐associated proteins
C. M. de Bont, N. Eerden, W. C. Boelens, G. J. M. Pruijn
Circulating serum miR‐223‐3p and miR‐16‐5p as possible biomarkers of early rheumatoid arthritis
M. Dunaeva, J. Blom R. Thurlings, G. J. M. Pruijn
Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for rheumatoid arthritis
Q. Luo, L. Zhang, X. Li, B. Fu, Z. Deng, C. Qing, R. Su, J. Xu, Y. Guo, Z. Huang, J. Li
LAIR‐1 shedding from human fibroblast‐like synoviocytes in rheumatoid arthritis following TNF‐α stimulation
Y. Zhang, S. Wang, H. Dong, X. Yi, J. Zhang, X. Liu, R. Zhuang, Y. Ding
Changes in anti‐citrullinated protein antibody isotype levels in relation to disease activity and response to treatment in early rheumatoid arthritis
A. Kastbom, K. Roos Ljungberg, M. Ziegelasch, J. Wetterö, T. Skogh, K. Martinsson
Carbamylation reduces the capacity of IgG for hexamerization and complement activation
R. Lubbers, S. C. Oostindie, D. J. Dijkstra, P. W. H. I. Parren, M. K. Verheul, L. Abendstein, T. H. Sharp, A. de Ru, G. M. C. Janssen, P. A. van Veelen, E. T. J. van den Bremer, B. Bleijlevens
Secretory antibodies to citrullinated peptides in plasma and saliva from rheumatoid arthritis patients and their unaffected first‐degree relatives
A. Svärd, K. Roos Ljungberg, M. Brink, K. Martinsson, C. Sjöwall, S. Rantapää Dahlqvist, A. Kastbom
Tumour necrosis factor α augments the inhibitory effects of CTLA‐4‐Ig on osteoclast generation from human monocytes via induction of CD80 expression
K. Oi, T. Tokunaga, T. Kuranobu, K. Yukawa, H. Kohno, Y. Yoshida, S. Mokuda, S. Hirata, E. Sugiyama
Altered metabolic pathways regulate synovial inflammation in rheumatoid arthritis
U. Fearon, M. M. Hanlon, S. M. Wade, J. M. Fletcher
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