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Targeting Immunometabolism

Therapeutic exploration and understanding of the specific intracellular metabolic pathways in immune cells

Special Collection Editor: Associate Professor Marianne Boes, University Medical Center Utrecht, Netherlands

The field of immunometabolism has matured into a vibrant translational research area in the last decade. Immunometabolism concerns the interplay of immunological and metabolic processes in health and disease, and can be a major influencing factor and driver in other conditions like autoimmune and infectious diseases, cancer and obesity. In this Special Collection, we will provide a comprehensive overview on metabolites and micronutrients in both hosts and pathogens and how they contribute to driving immune responses. We will be looking to cover the translational pipeline from discovery research and preclinical models right through to clinical and pharmaceutical research as it is applied to immunotherapeutics in the treatment of autoimmune and infectious diseases, as well as cancer.

We welcome original research, reviews, commentaries and TrialsWatch articles addressing a range of topics that contribute to our understanding of metabolic pathways in immune cells, including:

  • Altered metabolism in the tumour microenvironment, its impact on tumour immunity and immunotherapeutic potential
  • Immunomodulation by bacterial metabolites and their targeting for immunotherapy
  • Metabolic programming in immunocyte subsets – sugars, fatty acids, amino acids
  • Metabolic disease, obesity, immune function and implications for immunotherapy
  • Micronutrients, immune fitness and enhancing immunity.

We are also interested in articles summarising recent advances in studies of metabolic reprogramming, including first-in-human studies and negative clinical trials where they provide a mechanistic insight.

A glutamine “tug-of-war”: Targets to manipulate glutamine metabolism for cancer immunotherapy 

L J Pallett, S Dimeloe, L V Sinclair, A J Byrne, A Schurich

Type 2 immunity is maintained during cancer associated adipose tissue wasting 

Patrick J Lenehan, Assunta Cirella, Amiko M Uchida, Stephanie J Crowley, Tatyana SharovaGenevieve Boland, Michael Dougan, Stephanie K Dougan, Max Heckler

Targeting immunometabolism to treat COVID-19 

Shane Myles O’Carroll, Luke A J O’Neill