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Senior Scientist - B cell immunologist

GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to support our mission to improve the quality of human life by enabling people to do more, feel better and live longer.

Thye have an exciting opportunity available for an enthusiastic and innovative immunologist/cell biologist to join GSK’s Immunology Research Unit (IRU) in Stevenage. You will be working in a stimulating and fast-moving environment, where they put great emphasis on high quality science. Within this context and building on GSK’s capabilities in B-cell therapeutics, the role will be within the B cell biology team to help identify new targets and drive new B-cell therapies through to early clinical development.

As a senior scientist level biologist, you will have the opportunity to contribute to their target identification, validation and lead optimisation efforts. This will involve using unprecedented genetic resources through GSK’s collaboration with 23andMe, FinnGen and Open Targets combined with cell specific epigenetic datasets and functional genomic screens to identify pathogenic cell types, pathways and targets. You will also support biological validation and progression of their growing portfolio of novel genetically associated targets through establishing relevant in vitro cellular and tissue-based assay systems.

Key Responsibilities:

  • As a cell biologist contributing to the validation, characterisation and progression of novel targets and therapeutics to treat diseases associated with dysfunctional B cells
  • Establishing novel B-cell based cellular assay systems that mirror key aspects of disease for use in target validation and progression
  • Provide in vitro biology support for progression of the departments established research and lead optimisation programs through to clinical candidate selection
  • Collaborating with key academic or clinical alliances (or CROs) who can help further the programs or provide insight into the mechanism of action or therapeutic potential.
  • Maintain an active knowledge of external developments in the field and adapting/initiating work plans (internally and externally) in response to emergent data
  • Representing the Research Unit at external meetings and authoring publications in peer-reviewed journals 
  • Engagement and sharing expertise with wider IRU

Why you? 

Basic qualifications:

They are looking for professionals with these required skills to achieve their goals:

  • Science graduate with additional research experience ideally in industry or new PhD in Cell Biology or related discipline
  • Strong understanding of immunology, preferably B cell immunology, gained through research experience
  • Experienced in cell and molecular biological and immunological techniques to characterise cell phenotype and support target validation e.g. gene expression analysis, immunocytochemistry, flow cytometry and immunoassays
  • Knowledge and interest in technologies for immunophenotyping and genetic or genomic approaches to understand cellular phenotypes and gene function (e.g. mass cytometry, scRNAseq, CRISPR)
  • Comprehensive expertise in experimental design, execution, assay development and analysis
  • Excellent written and verbal communication skills

Preferred qualifications:

If you have the following characteristics, it would be a plus:

  • Experienced and proficient in the isolation, stimulation and functional characterisation of primary human immune cells, particularly B cells
  • Experience of early target discovery approaches and disease phenotyping
  • Experienced and proficient in computational analysis of large biological datasets

The successful candidate will need to have excellent interpersonal skills, being able to work effectively in a multidisciplinary team as well as independently under general supervision within GSK and to interact positively and effectively with collaborating scientists in both industrial and academic labs.