The Jonathan Boulter Memorial Lecture 2013

 
Integrated Department of Immunology, School of Medicine,
University of Colorado, Denver, USA
 
 

Wednesday, 9th October 2013
New Lecture Theatre, Michael Griffith Education Centre, School of Medicine, Heath Park
4:00 pm
 
The Jonathan Boulter Memorial Lecture 2013:  "Vaccine Adjuvants"
 
(free wine reception after the lecture)

Thursday, 10th October 2013
Seminar Room UG16, Henry Wellcome Building, Heath Park
1:00 pm
 
Science Seminar:   "T cell receptor functions"
(free lunch buffet from 12:30)
 
 
 
This event is kindly supported by
 
 
 
Philippa Marrack is a world-renowned immunology researcher whose groundbreaking work on T-cells has impacted the health of people across the world. Her findings shape medicine’s current understanding of the human immune system, vaccines, HIV, and other immune disorders.
 
Working in the labs at National Jewish Health in Denver, Philippa Marrack and her husband and fellow researcher, John Kappler, were among the first in the world to isolate the T-cell receptor, a crucial component of the immune response that identifies foreign invaders inside the body and destroys them. As a direct result of this research, Marrack discovered how the T-cells that could target the body's own tissues are destroyed in the thymus before they can cause problems. It's when rogue cells are not destroyed that they cause destructive autoimmune diseases like AIDS, diabetes, MS, and lupus. Philippa Marrack and John Kappler also discovered superantigens, powerful toxins that stimulate large numbers of T-cells and can cause devastating immune responses and violent symptoms such as those seen in toxic shock syndrome or food poisoning.
 
Their laboratory is interested in the basic biology of lymphocytes and application of knowledge about lymphocytes to human disease. Much of their work concentrates on T cells and their peculiar ability, via their aß T cell receptors (TCRs), to react with foreign antigens when these are bound as peptides to major histocompatibility complex proteins (MHC) of the host. Philippa Marrack and John Kappler are interested in the structural reasons for this bias, the role of evolution in creating the bias, and the ability of T cells to distinguish between different alleles of MHC proteins, an ability which affects the health of the host and rejection of transplants. T cells not only protect against infection but also drive autoimmune and allergic diseases and, potentially, could play a role in rejection of cancers.
 
The laboratory studies the interactions between TCRs and their target antigens in these various conditions with the goal of understanding why autoimmune disease and allergies occur in only some individuals and of improving cancer vaccines. Philippa Marrack and John Kappler would also like to improve the formulations of vaccines and study an adjuvant, alum, that is commonly used to increase the efficiency with which vaccines prevent diseases. Finally in an effort to understand why some autoimmune diseases occur more frequently in women than men, Philippa Marrack and John Kappler have recently described a population of B cells with unexpected properties that may account for some of this bias, both in humans and mice.
 
Born in England, Marrack earned her doctorate of philosophy degree in biological sciences at Cambridge University. She came to the United States for postdoctoral research and met her lifelong scientific partner and husband, John Kappler. They joined the faculties at National Jewish Health and the University of Colorado Health Sciences Center in 1979.
 
During her career, Marrack has published more than 350 peer-reviewed journal articles, attracting >45,000 citations in total (h-index 104). As ranked by citations and the impact of printed journal articles, she is the third most influential researcher in the nation and the top female researcher. She has been a member of the U.S. National Academy of Sciences since 1989 and a fellow of the Royal Society in Great Britain since 1997. Marrack was elected to the prestigious international Institute of Medicine in 2008.
 
Professional Experience:
1970-1971 Research Bye Fellow, Girton College, Cambridge, England
1970-1971 Postdoctoral Fellow, MRC Laboratory for Molecular Biology, Hill's Road, Cambridge, England
1971-1973 Postdoctoral Fellow, Damon Runyon Society for Cancer Research, Department of Biology, University of California at San Diego, La Jolla, CA
1973-1974 Postdoctoral Fellow, Department of Microbiology, University of Rochester, Rochester, NY
1974-1975 Associate, Department of Microbiology, University of Rochester, Rochester, NY
1975-1976 Assistant Professor, Department of Microbiology, University of Rochester, Rochester, NY
1976-1981 Established Investigator, American Heart Association
1976-1979 Assistant Professor of Oncology in the Department of Microbiology and Cancer Center of the University of Rochester, School of Medicine and Dentistry, Rochester, NY
1979-1982 Associate Professor of Oncology in the Department of Microbiology and Cancer Center, University of Rochester
1979- Member, Department of Medicine, National Jewish Hospital and Research Center, Denver, CO
1980-1985 Associate Professor, Departments of Biophysics, Biochemistry and Genetics and Department of Medicine, University of Colorado Health Sciences Center, Denver, CO
1985- Professor, Departments of Biophysics, Biochemistry and Genetics (now Dept. of Biochemistry and Molecular Genetics) and Medicine, University of Colorado Health Sciences Center, Denver, CO
1986- Investigator, Howard Hughes Medical Institute at Denver, Denver, CO
1988-1994 Professor, Department of Microbiology and Immunology, University of Colorado Health Sciences Center, Denver, CO
1988-1990 Head, Division of Basic Immunology, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO
1994- Professor, Department of Immunology, University of Colorado Health Sciences Center, Denver, CO
1998-1999 Head, Division of Basic Immunology, National Jewish Medical and Research Center, Denver, CO
2004- 2006 Advisory head, Research in allergy/asthma at National Jewish
 
Other Duties:
1977-1979 Member of Program Committee, AAI
1980-1984 Member, Immunobiology Study Section
1981 & 1983 Vice Chairman then Chairman, Gordon Conference on Immunochemistry and Immunobiology
1981-1984 Associate Editor, Journal of Immunology
1982-1984 Block Chairman, AAI organization for FASEB meeting
1983 Member, Ad hoc Research Briefing Panel of Immunology National Academy of Sciences
1983- Editorial Board, Cellular Immunology
1984-1987 Section Editor, Journal of Immunology
1984-1986 Member, Editorial Committee, Annual Review of Cell Biology
1985- Advisory Editor, Journal of Experimental Medicine
1985-1987 Block Chairman, AAI organization for FASEB meeting
1986-1991 Editorial Board, The FASEB Journal
1986- Advisory Board, Cancer Research Institute
1987- Associate Editor, Cell
1987-1991 Member, American Cancer Society Council
1989- Sandoz Award-Selection Committee 1988-1989 Reviewing Editor, Science
1991-1995 Member, Council of National Institute for Allergy & Infectious Diseases
1992-1993 Member, Council of the American Society for Cell Biology
1992- Advisory Editor, Therapeutic Immunology
1992- Editor, Current Opinion in Immunology
1993- Lasker Award Selection Committee
1995 Secretary General, International Union of Immunologists 'Tri-Annual Meeting, San Francisco, CA
1995-1998 FASEB Excellence in Science Award Committee
1995- Charter Member, Board of Molecular Medicine Society and Contributing Editor, Molecular Medicine
1995- Council, American Association of Immunologists
1996-2003 Member, Scientific Advisory Board, Pew Foundation
1997- Editorial Board, Journal of Autoimmunity
1997-2003 Editorial Board, Proceedings of the National Academy of Science
1997-2004 Scientific Advisory Board, Trudeau Institute
1998 Member, NIH Panel for review of the Director of NIAID
1998-1999 Member, Panel on Scientific Boundaries for Review
1998-2001 Vice President, International Union of Immunological Societies
1998-2002 Member, Center for Scientific Review Panel on Scientific Boundaries for Review
1998- Member, Scientific Advisory Board, Sandler Program for Asthma Research
1999-2000 Vice President, American Association of Immunologists
2000- Member, External Research Advisory Board, Joslin Diabetes Center
2000-2001 President, American Association of Immunologists
2000- Advisory Board, Genome Biology
2001 Member, Review Committee for Experimental Immunology Branch, NCI
2001-2004 President, International Union of Immunological Societies
2001-2004 Member, Burroughs Wellcome Fund Pathogenesis of Infectious Disease Advisory Committee
2001- Member, Editorial Board, Journal of Biology
2001- Member, Editorial Committee, Annual Review of Immunology
2002- Member, Editorial Board of Immunity
2002- Member, Nominating Committee for the National Academy of Sciences Class IV TNG
2002- Member, Scientific Foundation of Ireland, Scientific Advisory Committee
2003- American Federation for Aging Research Advisory Board
2003- Editorial Board, Public Library of Science
2003 National Academy of Sciences Nominating Committee for the next NAS president
2004- Non-Trustee Member, Committee on Scientific Affairs, Rockefeller University
2004- Past President, International Union of Immunological Societies
2005- Member, Review Panel for L’Oreal Awards to Women in Science
2005- Member, Royal Society International Network/Special Initiatives Committee:7
2005, 2006 Ad hoc member, CMI-A Study Section
2006- Evaluator, NIH Director’s Pioneer Awards
2006 Member, search committee for Proc. Natl. Acad. Sci USA editor
2006 Reviewer, Georgia National Science Foundation
2006 Chair, AAI Nominating Committee
2006 Member, NIAID Blue Ribbon Panel on Influenza Research
2006 Member, Class II, Section 2 Membership Panel for the American Academy of Arts and Sciences
2006 Ad hoc member of NIH Special Emphasis Panel, T cell/B cell mechanisms
2007-2008 ACD working group on changes in the grant review system
2007- Member, Scientific Advisory Board, Sandler Asthma Based Research Effort, UCSF
2007- External reviewer, NIH Director’s New Innovator Awards
2007- NY Academy of Sciences, Board of Editorial Consultants, Year in Immunology
2007-2008 Reviewer, HHMI new investigator competition
2007- Chiba University, Visiting Professor
2008 Ad hoc member, CMI-A Study Section
2008- Editorial Board, Proceedings of the National Academy of Science
2008- Member UCHSC CFAR Executive Committee
2008 Reviewer, Department of Immunology, Baylor University
2008- Member, Scientific Review Board, Damon Runyon Fellowships
2009- Member Wellcome Trust Principal Research Fellowship Interview Committee
2009- Member, Paul Ehrlich and Ludwig Darmstädter Prize Committee
2009- Member, American Foundation for Aging Research Advisory Council
2009 Member ZRG1 IMM-H Study Section
2009- Member, European Research Council
2009 Member, Panel for NRC dodecal review of NASA microgravity program
2009 Reviewer NIAID Challenge Grants
2010- Reviewer Gates Foundation Global Challenge Grants
2012- Member, National Advisory Council for Complementary and Alternative Medicine
2012- Member, Gates Foundation Discovery Expert Group

Honors:
1989- Member, National Academy of Sciences, USA
1990 Feodor Lynen Medal for Special Achievement and Distinguished Service Award
1990 Royal Society Wellcome Foundation Prize Winner and Lecturer
1990- Honorary Member, Scandinavian Society for Immunology
1990 The Arthur B. Lorber Award for Distinguished Service to National Jewish Center for Immunology and Respiratory Medicine
1991 Honorary Doctorate of Sciences, University of Rochester
1991- Fellow, American Academy of Arts and Sciences
1992 Christopher Columbus Discovery Award for Biomedical Research
1992 The Ernst W. Bertner Memorial Award, MD Anderson Cancer Center
1993 Cancer Research Institute's
1993 William B. Coley Award for Distinguished Research in Fundamental Immunology
1993 The Paul Ehrlich and Ludwig Darmstädter Prize, Germany
1993 University of Colorado Distinguished Professor
1995 The Louisa Gross Horwitz Prize-Columbia University
1995 FASEB Excellence in Science Award
1995 Behring-Heidelberger Lecture Award
1995 Dickson Prize in Medicine, University of Pittsburgh
1996 Honorary Doctorate of Sciences, Macalester College
1997- Fellow of the Royal Society
1998 The Rabbi Shai Schacknai Memorial Prize, Hadassah University, Jerusalem
1999 University of Chicago, Howard Taylor Ricketts Prize
1999 Interscience Conference on Antimicrobial Agents and Chemotherapy Award
2000 Member, American Academy of Arts and Sciences
2001 Irvington Institute Scientific Leadership Award in Immunology
2002 Member, The Academy of Medical Sciences
2002 Lifetime Achievement Award, American Association of Immunologists
2003 Faculty Ambassador Award, National Jewish Medical and Research Center
2004 L’Oreal UNESCO for Women in Science Award
2004 University of Colorado Health Sciences Center, School of Medicine, Mentoring Award
2004 National Jewish Medical and Research Center Abraham J. Kauvar Presidential Award
2005 Bonfils Stanton Award for Science
2005 National Jewish Medical and Research Center Lifetime Achievement Award
2005 Rockefeller University Pearl Meister Greengard Prize
2006 Avery-Landsteiner Prize of the German Society for Immunology
2007 Denver Business Journal Scientist Award
2008 Member, Institute of Medicine
2009 International Member, European Research Institute for Integrated Cellular Pathology
 

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South Wales
Immunology Group
 
 
 
 
 
Dr Ian Humphreys
Secretary and Treasurer
 
Dr Meike Heurich
Research Fellow Representative
 
Dr Joanna Giles
Postdoc Representative
 
 Sophie Wehenkel
Student Representative
 
 
The South Wales Immunology Group is kindly supported by:




 

 
Visitors since 23 Oct 2012:
Flag Counter
 
Visitors since 1 July 2010:
>24,000 visitors
from 131 countries
 

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