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Applications are invited for a fully funded Postdoctoral Research Fellow position in the McLoughlin Lab at the School of Biochemistry and Immunology, Trinity College Dublin.  The project will investigate the prospect of harnessing protective immune responses as an attractive approach for the development of novel therapeutic interventions, specifically towards the bacterium Staphylococcus aureus which causes a staggering 1 million deaths annually.

The project will employ cutting edge technologies (transcriptomics, metagenomics, in vivo infection models) to profile the phenotype and function of gdT cells during S. aureus infection in both pre-clinical models and in cohorts of S. aureus bloodstream infection patients, with a particular focus on dissecting the cytotoxic functions of gdT cells. State-of-the-art single cell metabolomic assays will be employed to explore the metabolic landscape that imbues gdT cells with the capacity to target intracellular S. aureus and so support the development of strategies to metabolically reprogramme these cells towards enhanced effector functions. This is a great opportunity to pursue cutting edge immunology research in the context of infection in a dynamic and supportive research environment. 

Appointment will be made on the Research Ireland Team Member Salary Scale at a point in line with Government Pay Policy: €45,847

An exciting opportunity to pursue a fully funded PhD studentship within the Host-Pathogen Interactions research group led by Prof Rachel McLoughlin (https://www.tcd.ie/Biochemistry/research/mcloughlin/) is available in the School of Biochemistry and Immunology at Trinity College Dublin.

They are looking for a highly motived candidate with an interest in host-pathogen interactions research. The successful student will 

• Produce an independent piece of research in the form of a PhD thesis/dissertation under the guidance and supervision of the Principal Investigator

• Attend courses and seminars on research methods that underpin the project. 

• Be encouraged to attend national and international conferences to present their research findings.

• Have the opportunity to publish in high impact journals.

As is the case for all registered PhD students at Trinity College Dublin, the candidate will undertake and complete a taught module or modules to accrue the required amount of ECT credits for the structured element of the TCD PhD programme.

Fixed-term Contract (48 Months) – Full-time

The successful candidate will receive an annual stipend of €22,000 plus fees for 4 years

Liverpool School of Tropical Medicine (LSTM) is a globally recognised centre of excellence for research and teaching in tropical diseases.

They are looking to appoint a world leading immunologist with a strong record of working in the human pathogen and/or tropical disease research areas, as a Professor of Immunology within our highly esteemed Tropical Disease Biology department. You will join a multidisciplinary group of experts with a shared interest in translating basic science into tangible solutions for the patients affected by global health challenges.

The successful candidate will have the autonomy to shape the research portfolio within immunology at LSTM. Some of the key areas they are keen to explore include world leading research across major human infections to address unmet global health challenges, increasing capability of relevant in-house infection models that link to refined animal disease and human challenge models, and leveraging the strength of existing LSTM research centres for the discovery of antibody-based biologics as diagnostic or therapeutic tools, to meet the needs of neglected tropical disease and/or emerging disease.

Healthy life expectancy is declining in the UK, particularly in deprived areas where the number of years spent in good health can vary by up to 26 years. The immune system is the body’s defence against infections and cancer, and a decline in immune system function contributes to increased disease burden in the elderly.

The aim of this project is to mechanistically investigate how phosphoinositide acyl chain composition regulates phosphoinositide dynamics, interlinked signal transduction, and cell function in aged human T cells.

T cells will be isolated from healthy human blood samples using age-matched male and female samples to compare age- and sex-driven phenotypes (ethics approved, sample size determined with power calculations).

Objectives

1. Elucidate how ageing impacts T cell phosphoinositide acyl chain composition and phosphoinositide dynamics.
2. Determine how acyl chain composition regulates phosphoinositide-protein binding and signal transduction.
3. Determine whether phosphoinositide acyl chain composition can be targeted to improve aged T cell function.

Key techniques

• Liquid Chromatography-Mass Spectrometry (LC-MS)
• Flow cytometry
• Processing human blood samples
• T cell phenotyping

The focus of the Associate Professor / Professor of Infection/Immunity will be to build a world-leading research programme, deliver excellent teaching, support the collaborative research culture and to positively engage with academic leadership both in the home Department(s) and across the School of Biological Sciences.

The successful applicant will have an excellent track record of implementing innovative solutions to address key research questions in the fields of infection or immunity, or at the intersection of these disciplines. Their research will accelerate research efforts within the School in the Grand Challenge areas: Changing pathogens in a changing world, Seeing infection through a new lens and Harnessing the immune system to fight disease (https://www.bio.cam.ac.uk/research/infection-immunity).

They will work within at least one of these Grand Challenge spaces, and potentially across multiple. Example research areas may include but are not limited to:

• Innovative computational biology approaches to study infection and immunity
• Vaccination technologies for both infectious and non-communicable diseases
• Comparative immunology across multiple species and scales (from cells to populations)
• New in vitro and in vivo models of host immune responses to infection
• In situ imaging of infection and immunity
• New tools to study and prevent vector-borne diseases

Salary: £62,098 (if appointed to Grade 10) or £67,757 (if appointed to Grade 11)

UKAS is looking for experienced laboratory-based immunologists (Biomedical Scientists, Clinical Scientists, and medical consultants) to join us on a third-party contractual basis as technical assessors to ISO 15189:2022.  The role involves assessing immunology laboratory services, either on site or remotely, to confirm the competence of the laboratory service to deliver a high quality, patient-focused diagnostic service. 

This is an opportunity to gain in-depth knowledge of  ISO 15189:2022 requirements and UKAS processes, enhance your immunology network by engaging with other UKAS technical assessors at regular update meetings, and support ongoing improvement in immunology laboratory service provision across the UK. 

The role is a great opportunity for experienced staff who are working in a laboratory service, as the laboratory benefits from the experience and knowledge technical assessors bring from UKAS training and assessments. It’s also a good opportunity for recently retired personnel to keep using their knowledge and skills to support continual improvement in medical laboratory service delivery across the UK. 

ProImmune is seeking a highly motivated person to join our Sales & Marketing team as a Graduate Product Specialist, responsible for spearheading collaborations and encouraging take up of our new Ankyron technology across primarily our UK & European territories.

Your Mission: Enable our customers to achieve their scientific goals. How? By identifying new opportunities, nurturing existing relationships, and promoting our cutting-edge products and service with specific focus on our groundbreaking Ankyron technology 

• Educate: Spread the word about Ankyrons - their potential, applications, and benefits.
• Market Explorer: Visit key prospects, close deals, and decode market trends (30% travel, mostly UK & EU)
• Solution Architect: Our customers have complex needs. Work with them to build solutions using our products and services.
• Leadership: Challenge the status quo. Your fresh perspective matters.
• Global Collaborator: Forge partnerships with researchers, institutions, and industry leaders and colleagues worldwide. While you’ll cover primarily the UK and Europe, your impact will ripple globally.

This role is ideally-suited to a new graduate or post-graduate (minimum of a BSc. in Immunology, Biochemistry, or a related field) with an outgoing personality looking for a financially rewarding long-term career combined with a way to capitalize on your scientific training.  We want someone who’s fired up and ready to contribute. Your enthusiasm will be contagious!

The Osaka University Immunology Frontier Research Center (IFReC) is recruiting post-doctoral researchers for its Advanced Postdoc Program. This program offers three-year employment and funding (3 million yen per year) for original research to promising young researchers. Selected applicants have access to continually upgraded state-of-the-art facilities at IFReC for their research, including equipment for single-cell analysis. Furthermore, selected applicants can expect their research careers to develop immensely through invaluable guidance from their supervisor among IFReC’s many distinguished Principal Investigators as well as through collaborative research with them. We look forward to receiving applications from ambitious young researchers. 

Annual Salary: JPY 5.7M - 7.7 M

Research Grant: JPY 3M per year

Period of employment: 1 year from the date of hire (renewable up to 3 years)