BSI jobs board

The role

We are looking for a highly motivated person who has an interest in translational research. You will provide technical support for the operation of academic gastroenterology, working under the guidance of Dr Chris Lamb in the Translational and Clinical Research Institute. This will involve carrying out complex research projects, experimental design, planning and progress of work along with quantitative & qualitative analysis. Work within the group aims to understand immune and microbial mechanisms responsible for inflammation in the intestine, with a particular focus on developing new and improved treatments for the inflammatory bowel diseases, ulcerative colitis and Crohn’s disease.  You will be required to work closely with Dr Andrew Filby the Flow Cytometry Core Facility team.

You should have the ability to work independently and on a flexible basis.  You should be enthusiastic, self-motivated and express a clear commitment to multidisciplinary and translational research.

The Person (Essential)

Knowledge, Skills and Experience

• Demonstrable work experience in a relevant technical / workshop role
• Thorough working knowledge of Health and Safety procedures
• Excellent team working skills
• Demonstrates technical and problem solving capability
• Demonstrates good organising ability to meet deadlines, with a positive and proactive approach to duties and diligence and attention to detail
• Contribute to design and specification of research/teaching activities
• Ability to adapt to changes in laboratory research priorities

Qualifications

• BTEC  HNC / HND; or A’ level (or equivalent) qualification; or broad work experience acquired through a combination of vocational training and considerable on-the-job experience, demonstrating development through progressively more demanding relevant roles.
• Professional registration with an accredited professional body (including HEA) or working towards this on appointment

The University of Glasgow are seeking a highly motivated, academically excellent and proactive Researcher with a strong background in dendritic cell biology/innate Immunity  and bioinformatics to join the groups of Dr Mariola Kurowska-Stolarska (Immunologist; principal investigator) and Dr Thomas Otto (bioinformatician) at the University of Glasgow.

The successful candidate will undertake translational research in a Pfizer-funded research project investigating JAK-regulated and synovial tissue macrophage-driven mechanisms of disease remission in Psoriatic Arthritis and Rheumatoid Arthritis. To achieve this goal, you will use innovative ex vivo models of human synovium and single-cell transcriptomic / spatial tissue transcriptomic technologies.

You will hold the position at the University of Glasgow, where you will be embedded in the multicentre Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), which includes researchers and clinicians from Glasgow, Oxford, Birmingham, Newcastle and collaborators in Gemelli Hospital in Rome. RACE is a world-leading research centre where discovery research drives development of transformative therapies for arthritis. You will benefit from an intellectually stimulating, vibrant international research/clinical environment and outstanding support facilities.

You will hold a BSc in Immunology and an MSc in bioinformatics and work towards a PhD in Immunology or Bioinformatics. You will demonstrate capacity to deliver research outputs, illustrated by your publication record. Expertise in a single-cell RNAseq technology is essential and the expertise in multiparameter flow/mass cytometry and primary cell-sorting is desirable.  

This is a full-time appointment fixed term for 3 years in the first instance, with a 6 months probation period. You will be required to upload a supporting statement, CV and names of referees as part of your online application.

An exciting opportunity has become available for a postdoctoral researcher to study the cellular immunology related to autoantibody-mediated diseases of the nervous system. This position is funded by a grant awarded to Dr Sarosh Irani from ONO Pharmaceuticals, via their alliance with the University of Oxford. This is an especially timely opportunity as the Irani group have a unique collection of patient samples and have recently published a series of high impact papers studying the autoantibodies and the B cell compartments.

This project aims to characterise the role of T cell and B cell interactions with a particular emphasis on the function of checkpoint molecules, PD-1 and CTLA-4, and the effects of drugs which target these proteins. This is an especially translational and patient-orientated contemporary area of immunology which has not yet been applied to the rapidly expanding field of autoimmune neurology. The Irani group are just beginning to study T cells in these diseases, and hence the postholder will play a formative role in the development of this field within the host laboratory.

The successful applicant will hold a PhD in immunology or a closely related field with extensive technical expertise in research methods within the field of immunology with special attention to multicolor flow cytometry and cell sorting, mammalian cell culture and molecular biology including PCR and RT-PCR. Research experience in the field of immunology and the ability to solve problems and demonstrate independent, critical scientific thinking skills are essential. Ideas for the development of innovative methods to study the immunobiology of patients with autoantibody CNS diseases and skills and or background in T cells and B cells would prove advantageous

At the University of Cambridge a post-doctoral research associate position in Professor Kaser's laboratory is available for a talented and motivated scientist to work on the biology of the key immune-metabolic enzyme. The laboratory studies genetically-affected pathways that predispose for immune-related diseases. They are looking for a scientist with a background in immunology, cell biology, biochemistry, structural and/or molecular biology to join our group to study a major immuno-metabolic pathway. They hope to recruit an enthusiastic and creative colleague who shares their passion for discovery and who looks for an exciting challenge within a multidisciplinary group.

The successful candidate will have a PhD in a relevant subject and be willing to supervise research students. A strong publication record, ability to work independently and good communication and presentation skills are essential. A personal Home Office License would be advantageous although not vital. Experience in immuno-metabolism would be ideal. The successful candidate will participate in an active programme of group meetings and departmental seminars, manage research project and associated administrative matters.

The lab is located in the Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID). The research and this post is funded by the Wellcome Trust and the European Research Council.