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Antibody Pharmacology at GSK comprises a team of 20+ assay scientists, immunologists and biologists who conduct functional assay design, screening and characterisation of potential antibody-based drug molecules. The team is an integral part of the Biopharmaceutical Molecular Discovery organization that is responsible for the discovery of candidate biologics across several Therapeutic Areas including Immuno-oncology, Respiratory, Immuno-Inflammation and Infectious Diseases.

They are seeking an experienced laboratory scientist with a deep understanding of antibody structure and function relationships, and in particular the contribution of Fc biology to the Mechanism of Action and PK/PD of an antibody.  The candidate will be expected to act as a Subject Matter Expert (SME) in Fc biology and be accountable for profiling Fc functions and selecting the most suitable Fc variant that produces the desired Fc functionality. 

Depending on experience,  the candidate may be responsible for leading and driving a Fc biology matrix team in designing novel in vitro assays that are disease relevant, and standardizing assays to accelerate the discovery process.

Key responsibilities:
•    Demonstrate scientific leadership through acting as a Subject Matter Expert in Fc biology; Stay abreast of the latest literature and developments in the field; Be accountable for selecting the most suitable Fc variant that produces the desired Fc functionality
•    Collaborate with other functions within GSK R&D, especially Antibody Technology and Translational Science; Devise and implement a Fc biology strategy that supports the discovery and development of best-in-class antibody drug candidates 
•    Influence Drug Discovery Project Teams as an Antibody Pharmacology SME. Accountable for designing and conducting disease relevant functional assays and Fc biology assays; Deliver timely quality data packages that enable project decision-making and progression
•    When suitable, participate in relevant technology projects that optimise/modernise the antibody drug discovery process
•    Be able to publish and present both internally and externally

On offer is a collaborative learning environment and the opportunity to develop your career and gain experience across drug discovery. If you share the priorities of innovation, performance and trust and are motivated to contribute towards bringing lifesaving drugs to patients, then we'd love to hear from you.

An unique opportunity is available to pursue a GSK funded PhD studentship within the Host Pathogen Research Group at the school of Biochemistry and Immunology at Trinity College Dublin (TCD), in collaboration with GSK Vaccines, Siena. The chosen candidate will have the unprecedented opportunity to obtain a PhD from Ireland’s premier research University while training in applied immunological research at the worlds largest vaccine research company, thus equipping the individual with a unique skill set to pursue a successful research career within industry or academia.

The student will join a multidisciplinary team of academic and industrial immunology researchers investigating Staphylococcus aureus immunity. S. aureus is the leading cause of skin and soft tissue infections (SSTI), which are common, frequently recurrent and often caused by antibiotic-resistant strains. In addition, SSTI are a primary entry portal for invasive infection. Therefore, a vaccine that protects against S. aureus SSTI is a major medical need. Human skin contains twice as many T cells than blood. Skin-resident memory T cells (TSRM) permanently reside in the skin forming the first line of adaptive immunity against re-infection. The goal of this project is to assess the role of TSRM in protection against primary and recurrent S. aureus SSTI and how vaccination can exploit this response. The ability of different adjuvants to modulate the TSRM response will be also evaluated.

This PhD project will utilize an in vitro model of human skin explant and an in vivo murine model of recurrent SSTI. The student will acquire technical expertise in human and mouse immunology, microbiology, confocal microscopy and immunohistochemistry, human skin explants, adjuvants and formulation science.

The studentship will be for 4 years and the successful applicant will be expected to have a first class honors degree or a high upper second in a biological subject (preferably with a significant immunology component). The student will be based primarily at the GSK Vaccine Research Campus in Siena, Italy where they will join an established group of PhD students as part of the Vaccine Academy. They will work under the direction of the company supervisor Dr Elisabetta Soldaini, PhD, Senior Scientist in the Preclinical Evidence Generation – Immunology Function at the Research Center of GSK.

Following a recent major award, our Diabetes Centre of Excellence is expanding substantially.

This permanent, full time or part time post is available at the University of Exeter Medical School, College of Medicine & Health, based in Exeter.

Summary of the role

The post holder will lead a dynamic research group which will develop ideas, secure funding and deliver innovative research projects, they will supervise and enthuse undergraduate and postgraduate students in research and excel at teaching. The post holder will produce research outputs at an appropriate level and disseminate their research to academic, healthcare and patient communities. Collaboration with other colleagues in the College of Medicine and Health, the Living Systems Institute, Centre for Medical Mycology and Institute for Data Science and Artificial Intelligence is very much encouraged as is the development of external national and international collaborations.

Applications from specialists in Immunology are very welcome. The immunologists will be able to work on novel and pioneering approaches using unique human pancreas samples obtained at the time of diagnosis of type 1 diabetes. The ultimate aim is to understand the underlying disease processes in order to stimulate the development and application of novel immunotherapies and inform the design of new clinical trials.  The availability of our new high-resolution, automated, digital pathology system will support this work by superseding current more laborious methods of image analysis.  Interdisciplinary work will be with our Living Systems Institute.

A particular interest in individuals who:

will bring their leadership, tools and skills and contribute their expertise to this diabetes research in the areas of Bayesian Statistics, Artificial Intelligence, Immunology and Cell Biology
and have educational strengths in the above areas
Applications welcome from individuals who have the skills described above but who have not, as yet, applied those skills to diabetes research but are keen to do so, as well as those already working in diabetes and its associated conditions.

This is an exciting opportunity for a post-doctoral scientist to perform laboratory research on the development of new assays for the assessment of Group B Streptococcal immunity at St George’s, University of London (SGUL).The principal role of the post holder will be to undertake research in mucosal immunity to GBS, helping to advance a high-level research programme in the laboratory of Dr. Le Doare, and in close collaboration with Prof Heath, Vaccine Institute Director. The scientist will have the opportunity to develop a programme of high-level academic research in collaboration and interaction with Harvard University, USA. The post holder will have a strong interest in immunology and/or infection and experience of scientific data handling. He or she will also participate in the other clinical and research activities linked to the PIDRG and the St George’s Vaccine Institute. The post is funded for one year in the first instance, but may be renewable.

Flexible working, including part-time or reduced hours of work, opportunities to work from home for many posts, compressed hours and local flexibility in agreeing start and finish times of work are among the extra benefits offered by St George’s, University of London.