BSI jobs board

This role is for 21 hours (0.6 FTE) a week.

Exciting opportunity for a talented Personal Assistant to join our team to ensure the effective running of our Society.

We are looking to recruit a motivated and talented individual to support the CEO and the wider Senior Management Team (SMT) to ensure the smooth and effective running of the senior tier of the organisation. You will provide high quality PA support across the SMT as well as providing information management support and often be the first point of contact for the CEO. You will be responsible for organising all the BSI’s committee and group meetings.

The role includes supporting the SMT to manage their time effectively through diary management and meetings. This includes responsibility for the CEO’s diary and contacts and support email inbox management. You will also prepare minutes and ensuring actions are followed up for SMT meetings, as well as Board and committee meetings as appropriate.

This role is crucial to the effectiveness of the SMT and the organisation. You will interact with the whole BSI team, the Board, BSI members and the wider immunology community. You will undertake a wide range of activities that are vital to the operation of the SMT, the BSI and its members, working with teams across the organisation as well as key external contacts.

We offer a hybrid working model, with most time spent working from home with an office space in Holborn available two days a week.

If you feel that you have the required skills for this role, please read the full job description and send your CV and a cover letter outlining your suitability for the role to hr@immunology.org by noon Thursday 8th December 2022.
Interviews will be held on Thursday 15th December.

Unfortunately, due to the volume of applications that we receive, it is not possible to respond to all applicants individually. We request no contact from agencies.

Full time (5 days a week), permanent contract

We’re looking for a Marketing & Communications Officer with a strong understanding and passion for science and for creating captivating communications.

The BSI is an influential and authoritative voice for immunology, a key scientific and health field that plays a central role in many of the most pressing global health challenges we face. Now is an exciting time for immunology, which is seeing new therapies (such as novel vaccines and cancer immunotherapies) come into the clinic to improve patient health.

This is a fantastic opportunity for someone with excellent communication and organisational skills who is looking for an exciting new challenge. If you’re an ambitious and self-driven communications professional eager to build your skills through high-profile projects in the charity sector, this is the job for you!

The role
As an integral member of our team, you will deliver engaging communications to a range of audiences (including scientists, the media, policy makers and the public) through a variety of channels (including website, newsletters, social media and events) to drive the reach and influence of immunology and the Society’s work. This includes campaigns with a focus on membership engagement, promoting our events and generating content that is informed and shaped by our immunology community. 

You will collaborate across teams to support the organisation’s activities, working closely with the Marketing & Communications Manager and the Officer as an essential member of the wider External Affairs team.

This creative and fast-paced role is an excellent opportunity to build your experience whilst working across a range of areas within a science and health membership organisation. You will be able to develop further in their career as part of a fun, hardworking and extremely ambitious team. We offer a hybrid working model, with most time spent working from home with an office space in Holborn available two days a week.

If you feel that you have the required skills for this role, please carefully review the job description before sending a CV and cover letter outlining your suitability for the role to hr@immunology.org by midnight (GMT), Thursday 8 December 2022. Interviews will be held on Friday 16 and Monday 19 December 2022.

About the Project
VEXAS (Vacuoles, E1-ligase, X-linked, Auto-inflammatory, Somatic) syndrome is a recently discovered, progressive systemic auto-inflammatory disorder associated with ageing. This condition is characterised by inflammation affecting multiple organ systems and bone marrow failure. Presently, there is no effective treatment. VEXAS is caused by myeloid-restricted somatic mutations in UBA1, which encodes an E1 ubiquitin ligase. This is completely novel mechanism to cause a non-malignant disorder. Pathogenic mutations associated with VEXAS are confined to exon 3, with Methionine-41 being a particularly important site where substitutions result in loss of cytoplasmic UBA1 (UBA1b) and its enzymatic activity. Presently, however, little is known about the evolution of pathogenic mutations in UBA1 and their effect on disease progression. Furthermore, the pathological relevance of newly discovered rare variants in UBA1 and related genes is unknown. 

The principal aims of this studentship are

• To set up a robust cell culture systems to study evolution of pathogenic UBA1 mutations and their effect on cellular differentiation, molecular programme, and disease progression.
• To determine the functional effects of newly discovered rare variants in UBA1 and related genes.

To achieve these aims the student will have access to a unique cohort of patients with VEXAS and VEXAS-like disorders who are recruited via one of the national centres for autoinflammatory diseases based at Leeds Teaching hospitals NHS Trust.

The experimental approach will include phylogenetic tree construction to determine timing/evolution of mutant clones

• Duplex sequencing (Nanoseq) to determine mutational signatures and
• intra-patient clonal assays to study UBA1-mutated and non-mutated clones. Functional assays to assess the pathogenicity of new UBA1 variants will involve transforming BL21 E. coli with human UBA1 containing either WT or variants, followed by protein extraction, purification and by using the ubiquitin thioester formation assay.

Finally, human inducible pluripotent stem cells (hiPSC) will be engineered to introduce novel variants and subsequently induced to develop hiPSC derived monocytes/macrophages which will be tested for pro-inflammatory cytokine production in response to relevant stimuli. In summary the student will have an opportunity to learn a range of molecular techniques and gain experience in analysing genetic and transcriptomic (RNAseq) data with core bioinformatic pipelines already embedded in the host laboratories. The student will become proficient in R by the end of their training.

Job description
Human Technopole (HT) is a new interdisciplinary life science research institute, created and supported by the Italian government, with the aim of developing innovative strategies to improve human health. 

The position of Postdoctoral Fellow position at the Domínguez Conde group aims to investigate mechanisms of gene regulation in the developing immune system using a range of single-cell cytometry and genomic technologies. They are seeking a highly motivated and self-driven individual to join them in a quest to improve the molecular understanding of human immune development in health and disease.

Main responsibilities

• Analysis and interpretation of multimodal single-cell sequencing datasets (including scRNA-seq, scATAC-seq and CITE-seq)
• Design of new approaches to integrate and query existing and newly generated single-cell datasets
• Implement/develop novel analytical methods to infer differentiation trajectories and gene regulatory networks (GRN) during human immune development
• Analysis of the clonal structure of developing immune cells via single-cell profiling of antigen receptor sequences
• Assessment of trajectory or GRN disruption in inborn errors of immunity
• Proactive interaction with the Genome Analysis Unit and the Genomics Facility for data generation and analysis

Job requirements (essential)

• PhD degree in immunology, genomics or bioinformatics
• Strong track record of previous research projects
• Experience with high-throughput sequencing data
• Fluency in English – HT is an international research institute

Job summary
Specialised services support people with a range of rare and complex conditions. They often involve treatments provided to patients with rare cancers, genetic disorders or complex medical or surgical conditions.

The NHS are seeking applications from clinical professionals who are keen and ready to take on an important national leadership role as National Clinical Director for Infectious Diseases.

Most importantly, they are seeking individuals from a broad range of clinical disciplines and backgrounds, who can bring fresh thinking and innovative ideas, informed by recent experience of clinical delivery in NHS Specialised healthcare.

The successful candidate will be offered 2 PAs per week with remuneration direct to the successful candidate's employer.

Applicants will need to have secured agreement from their host employer before applying for the role. Applicants should be a clinical professional working in England and should ordinarily work for an NHS trust or a university.

Main duties of the job
The role of the National Clinical Director (NCD) is to provide specialist clinical advice and leadership for NHS England across the high profile Infectious Diseases (ID) programme.

The role holder will lead the ID Clinical Reference Group and work alongside the Specialised Commissioning Senior Management Team and other stakeholders to deliver an ambitious agenda to improve the quality and value of ID services while ensuring that the programme is clinically focused.

Job responsibilities
The role of the National Clinical Director (NCD) is to provide specialist clinical advice and leadership for NHS England and NHS Improvement in these respects:

• clinical advice and leadership to drive transformation of services for patients
• clinical advice and leadership to support the commissioning of services
• clinical advice to support development of policy and parliamentary accountability

Person Specification

The following are the key areas the applicant needs to show experience and competence in for the role. 

• Leadership
• Collaboration
• Credibility
• Transformation
• Stakeholder engagement

The Lloyd lab at Imperial College London, funded by the Wellcome Trust, has embarked on a multidisciplinary project to investigate neuro-immune-stromal interactions in response to environmental change, and how this drives allergic airway inflammation and remodelling.

They use patient samples and neonatal/adult allergic airway mouse models to determine immune-neuro interactions and assess their impact on disease progression, pathology, and lung function (www.lloydlab.co.uk). 

To fully comprehend the complex interactions between the different cellular compartments in lungs, we are looking for an individual to develop and drive the integration of advanced imaging technologies and spatial transcriptomics. Data analysis will be a key component of this project and therefore a keen interest in mining complex data sets will be essential.

The successful candidate will have a PhD in a related discipline and be technically proficient in a range of laboratory skills, have the ambition and drive to succeed.

They are keen to hear from individuals with the following experience:

• Extensive Microscopy experience (Confocal, widefield, live cell imaging, intravital or IMC). Knowledge or experience of Second Harmonic Generation microscopy would be advantageous.
• Image Analysis and associated software including Image J, ICY, IMARIS, Huygens, Volocity, MCD, Cell Profiler, ilastik.
• Experience of single cell or bulk RNAseq, NGS, Spatial Transcriptomics or proteomics would be advantageous as would experience using R and/or python code for bioinformatics data analysis of multiplex datasets. Knowledge of MATLAB, Perl, CellPhoneDB, CellChat, NicheNet, Seurat.
• In vivo experience, preferably with a home office license - PIL A,B and C.

This post will provide the opportunity to develop and drive a research project as well as writing up work for presentation and publication. Therefore, the ability to work independently and as part of a team, have excellent communication, organisational and problem-solving skills are essential.

The Francis Crick Institute is breaking down barriers between basic and clinical research by supporting collaboration and the sharing of ideas, bringing more clinical expertise to the Crick and offering truly interdisciplinary training to scientists and clinicians.

Together with their partners, this helps them achieve their aim of creating the scientific leaders of the future and accelerates the movement of research ideas out of the lab and into clinical practice.

To ensure that ther clinicians can maintain links to clinical training and receive clinical mentorship, clinical fellows may be associated with external partners. 

This could be with one of their partner universities (University College London, Imperial College London and King's College London), with other universities, or with NIHR biomedical research centres and Cancer Research UK (CRUK) centres.

They're also part of the CRUK City of London Centre, which offers multidisciplinary cancer-based doctoral clinical fellowships as part of its training programme. 

Eligibility

• They are looking for talented and motivated postdoctoral clinical fellows who are passionate about research and show outstanding potential for continuing a career in academic medicine.
• Applicants should have completed a medical degree, or equivalent clinical professional qualification, and hold, or be about to hold, a research PhD.
• Applications are welcome from all medical and surgical specialties.

If you are passionate about the immune system and how it can be targeted to provide therapeutic solutions, love diversity of research, enjoy communicating and enjoy working in a collaborative and innovative environment please apply to join our team.

Who are Nexus BioQuest:

They are a new contract research organisation (CRO) providing scientific solutions and people resource to their clients looking to outsource research in the pre-clinical drug discovery space. They provide scientific resource, knowledge and experience to let their clients get their drug to the clinic faster.  Their ethos is to work collaboratively with our clients to enhance problem solving and provide immunology excellence and progress their drug discovery program. As a CRO their clients are diverse ranging from small biotech through to big pharma; this provides an exciting opportunity to work with many different clients and across multiple cutting-edge drug development projects.  
The focus of the company is immune-oncology research but they work in all areas where the immune system either drives disease such as autoimmunity, inflammation, neuro-inflammation, and in areas where the immune system provides potential therapeutic target solutions such as vaccine development, cellular therapies, gene therapies. 

The role:

They are looking for a collaborative, enthusiastic scientist to join our growing company. You will work within a small team to run diverse client projects, and be involved at all stages from planning, running experiments and reporting. A significant part of the role will be laboratory work, so problem solving skills and a passion for being at the bench and analysing data is a must. You should be a good communicator and keen to work in a team environment to bring projects to completion. There, will be a significant opportunity for you to grow your skill set and knowledge within the immunology space working within an inclusive small team environment.  

Who you are:

You should have a passion for working in immunology in the drug development industry. The role is suited to someone who enjoys diversity and working on varied projects. You should have a strong fundamental knowledge of the immune system and hold an MSc which involved study of some aspect of the immune system. The role could also be suited to a talented BSc student who’s degree focused on immunology and who has some experience working in a laboratory environment. You should be rigorous in your approach to data handling, analysis and presentation. Practical experience in one or more of the following areas is required:

• Cell culture of primary immune cells and cell lines
• Flow cytometry
• Imaging and image analysis
• qPCR/molecular biology
• Cytokine analysis (multiplexing)

Salary:

• £30,000 to £45,000 depending on experience

Benefits:

• Discretionary bonus system.
• EMI share options.
• Medical insurance.
• Life Insurance. 
• Critical health insurance.
• Relocation costs up to £1000.
• The opportunity to work in a fast paced, ground breaking industry sector

Who are Nexus BioQuest:

They are a new contract research organisation (CRO) providing scientific solutions and people resource to their clients looking to outsource research in the pre-clinical drug discovery space. They provide scientific resource, knowledge and experience to let their clients get their drug to the clinic faster.  Their ethos is to work collaboratively with their clients to enhance problem solving and provide immunology excellence and progress their drug discovery program. As a CRO their clients are diverse ranging from small Biotech through to big pharma; this provides an exciting opportunity to work with many different clients and across multiple cutting-edge drug development projects.  
The focus of the company is immune-oncology research but they work in all areas where the immune system either drives disease such as autoimmunity, inflammation, neuro-inflammation, and in areas where the immune system provides potential therapeutic target solutions such as vaccine development, cellular therapies, gene therapies. 

The role:

They are looking for a collaborative, enthusiastic Senior Scientist to join our growing company.  You will work within a small team to run diverse client projects, and be involved  at all stages from inception and planning, running experiments and reporting and presenting data to clients. A significant part of the role will be laboratory work so problem solving skills and a passion for being at the bench and analysing data is a must. You should be a good communicator and keen to work in a team environment to bring projects to completion. The role will involve providing mentorship to more junior scientists and give you the opportunity to acquire management skills. There, will be a significant opportunity for you to grow your skill set and knowledge within the immunology space.  

Who you are:

You should have a passion for working in immunology in the drug development industry. The role is suited to someone who enjoys diversity and working on varied projects. You should have a very strong fundamental knowledge of the immune system and hold an MSc or PhD which involved study of some aspect of the immune system. Ideally you will have 3years or more post-doctoral or equivalent industry experience. You should be rigorous in your approach to data handling, analysis and presentation. Significant practical experience in one of more of the following areas is required:

• Cell culture of primary immune cells and cell lines
• Flow cytometry
• Imaging and image analysis
• qPCR/molecular biology
• Cytokine analysis (multiplexing)

Salary:

• £40,000 to £55,000 depending on experience

Benefits:

• Discretionary bonus system.
• EMI share options.
• Medical insurance.
• Life Insurance. 
• Critical health insurance.
• Relocation costs up to £1000.
• The opportunity to work in a fast paced, ground breaking industry sector