The Babraham Institute is a charity which is world renowned for its research in life sciences to enhance lives and improve wellbeing.
They are seeking a dedicated and enthusiastic Postdoctoral Research Scientist to join the newly established laboratory of Dr Claudia Ribeiro de Almeida within the Lymphocyte Signalling and Development programme at The Babraham Institute. The Ribeiro de Almeida laboratory studies the emerging role of RNA and RNA binding proteins (RBPs) in controlling B lymphocyte development and immunoglobulin gene rearrangements.
They are interested in the mechanisms regulating immunoglobulin gene rearrangements and their potential implications for age-related immune dysfunction. The ideal candidate must have an interest in immunology and hands-on expertise in biochemistry and molecular biology will be considered an asset.
The post-holder will undertake a pivotal position in our current research to investigate the role of RNA helicases in class switch recombination (CSR) at the immunoglobulin heavy-chain locus. This includes employing state-of-the-art genomic and proteomic approaches to identify novel RBPs implicated in CSR, and exploring their molecular function using biochemical and cellular assays. This work may provide new targets to modulate B cell function during vaccination and immune disease, or uncover pathological mechanisms associated with the development of B cell malignancies.
The successful applicant should have a PhD in a biological science or equivalent qualification, and can demonstrate a proven track record in academic research. Experience of molecular biology, cell culture are essential. In addition, experience in mass spectrometry, Next Generation Sequencing methodologies and RNA biology are highly desirable.