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BSI jobs board

To post a job advertisement on this page, please contact our Education & Careers Officer, Eolan Healy. Note that this service is free to BSI members and their institutions, as well as our corporate members. There is a small charge of £100 for non-members who wish to advertise. 

Please note, all job vacancies are posted as soon as they are received, and are cleared after the closing date, or after three months, if one is not specified.

For more information about the vacancies, please click on the links below. You may also find it helpful to have a look at our funding opportunities page. 

Current vacancies

Postdoctoral research scientist (Mucosal immunology)

This 4-year Postdoctoral Scientist position is one several available within the Bill and Melinda Gates Foundation-funded Pirbright Livestock Antibody Hub. This hub will exploit the recent advances in our understanding of B-cell responses to better understand the protective immune response in livestock and poultry. It will address the needs of the research community and bridge the requirements of the vaccine industry. Overall the hub will support rational vaccinology approaches, antibody-based treatment and prophylaxis as well as increasing the applicability of animals as models for human disease and treatment.

The Postdoctoral Scientist will work within the Mucosal Immunology group and work closely with a multidisciplinary team to advance the aims of the overall Pirbright Livestock Antibody Hub. The postholder will utilise a wide range of immunological and virological techniques such as FACS analysis, ELISPOT, microneutralisation, virus propagation, plaque assays and other cellular approaches to:

  1. exploit the pig as a large-animal model for influenza virus infection
  2. identify alternative mechanism of protection beyond virus neutralization
  3. help characterize the Fc receptor gene content and the understanding of the function of each Fc receptor in cattle, poultry and pigs
  4. help development a suite of assays to examine the function of individual antibodies (recombinant or native) for several species

Responsible for conducting research into immunity and antibody therapeutics against influenza viruses:

  • Assist with conducting pig influenza studies
  • Preparation of virus challenge material and quantification of virus load in tissues (PCR and plaque assays)
  • Analysis of B and T cell responses after influenza infection and/or immunisation (T and B cell ELISpot, Flow cytometry, cell proliferation).
  • Determination of antigen specificity and function of mAbs (microneutralisation, ELISA, HAI, ADCC).
  • Contribute to developing of new techniques and methods
  • generate standardised in vitro assays to measure antibody-dependent cellular cytotoxicity (ADCC) and antibody directed cellular phagocytosis (ADCP)
  • develop in vivo assays to define the function of each all the IgG subclasses, IgA and IgM
  • study binding and affinity of each antibody subclass to that species Fc receptors, in several species

Responsible for working as part of an established team, which will include:

  • Communicating progress and data
  • Disseminate results through writing high quality peer-reviewed manuscripts and presenting at scientific meetings       
  • Developing and maintaining documentation associated with the health, safety and biosecurity of the research to preserve a safe working environment.
  • Assist with lab management (ordering, looking after equipment, sample inventories)
  • Supervision and training of group members
Institution/Organisation:
Pirbright Institute
Application deadline:
External link:
Further information
Postdoctoral Scientist (Influenza Viruses)

This 4-year Postdoctoral Scientist position is one several available within the Bill and Melinda Gates Foundation-funded Pirbright Livestock Antibody Hub. This hub will exploit the recent advances in our understanding of B-cell responses to better understand the protective immune response in livestock and poultry. It will address the needs of the research community and bridge the requirements of the vaccine industry. Overall the hub will support rational vaccinology approaches, antibody-based treatment and prophylaxis as well as increasing the applicability of animals as models for human disease and treatment.

The Postdoctoral Scientist will work at 50% within the Avian Influenza Group to carry out research to unravel the molecular structure of antigens and antibodies critical for neutralisation of avian influenza. 

50% of the time will be dedicated to help organise in vivo experiments in poultry, and occasionally pigs, for the analysis of B-cell responses following vaccination or challenge with different economically important pathogens. The role will include liaising with different scientific groups and the Animal Services department, helping to collect samples from animals and assisting with processing samples in the laboratory.

Responsible for conducting in vivo studies, which will include:

  • Liaising with groups within Science and Animal Services to plan experiments
  • Experimental design, logistics of the experiments and statistical data analysis
  • Holding a Home Office personal Licence under the Animals (Scientific Procedures) Act 1986 (as amended 2012)
  • Meticulous attention to detail including record keeping, document control and the ability to adhere to written methods & protocols.
  • Carrying out regulated procedures
  • Vaccination of chickens and eggs
  • Assessment of clinical signs
  • Collection and analysis of tissue samples                                                                            

Responsible for molecular virology, which will include:

  • AIV reverse genetics
  • Recombinant protein and antibody production
  • Development of viral vectored vaccines using CRISPR-Cas9 
  • Cell and tissue culture
  • Characterisation of recombinant viruses in vitro
  • Virus neutralisation assays
Institution/Organisation:
Pirbright Institute
Application deadline:
External link:
Further information
Postdoctoral scientist (Coronavirus)

This 4-year Postdoctoral Scientist position is one several available within the Bill and Melinda Gates Foundation-funded Pirbright Livestock Antibody Hub. This hub will exploit the recent advances in our understanding of B-cell responses to better understand the protective immune response in livestock and poultry. It will address the needs of the research community and bridge the requirements of the vaccine industry. Overall the hub will support rational vaccinology approaches, antibody-based treatment and prophylaxis as well as increasing the applicability of animals as models for human disease and treatment

Responsible for molecular virology, which will include:

  • Reverse genetics
  • Cell and tissue culture
  • Characterisation of recombinant viruses in vitro
  • Virus neutralisation assays    

​​Responsible for in vivo studies, which will include:

  • Experimental design and statistical data analysis
  • Vaccination of chickens and eggs
  • Assessment of clinical signs
  • Collection and analysis of tissue samples

Responsible for working as part of an established team, which will include: 

  • Communicating progress and data
  • Disseminate results through writing high quality peer-reviewed manuscripts and presenting at scientific meetings       
  • Assist with lab management (ordering, looking after equipment, sample inventories)
  • Supervision and training of group members
Institution/Organisation:
Pirbright Institute
Application deadline:
External link:
Further information
Research technician (Immunogenetics) X2

This 4-year position is one several available within the Bill and Melinda Gates Foundation-funded Pirbright Livestock Antibody Hub. This hub will exploit the recent advances in our understanding of B-cell responses to better understand the protective immune response in livestock and poultry. It will address the needs of the research community and bridge the requirements of the vaccine industry. Overall the hub will support rational vaccinology approaches, antibody-based treatment and prophylaxis as well as increasing the applicability of animals as models for human disease and treatment.

This position will focus on flow cytometry to isolate single antigen-specific B cells by FACS in ruminants, poultry and pig and link to a high-throughput sequencing work program to sequence antigen-specific immunoglobulin genes from single isolated cells.

Responsible for single B-cell isolation by flow cytometry, which will include:

  • Coupling antibodies and antigens to fluorochromes
  • Analysis of B-cell subsets by flow cytometry using panels of antibody/fluorochromes
  • Adapt the panels to several species
  • Optimise antigen staining and antigen-specific B-cell characterisation by flow-cytometry
  • Sort antigen-specific single-B cell by FACS and other technologies

Responsible for sample preparation for next generation sequencing, which will include:

  • Amplification of the heavy and light chains of the immunoglobulins by PCR in several species
  • Preparation of sequencing libraries for single B cell sequencing, RNA-seq and whole genome sequencing as required, in addition to using an automated laboratory robotics system for library preparation
  • Interacting with Illumina sequencers – including loading/unloading runs and equipment maintenance
  • Quality control of sample libraries prior to library preparation and sequencin

Responsible for working as part of an established team, which will include

Contribute to the overall research group

Institution/Organisation:
Pirbright Institute
Application deadline:
External link:
Further information
Postdoctoral Clinical Fellows

The Francis Crick Institute is currently recruiting for Postdoctoral Clinical Fellows. 

Postdoctoral career development fellowships provide an opportunity for exceptional postdoctoral clinicians to consolidate their research experience.

Postdoctoral clinicians may apply for Crick or Crick-Cancer Research UK funding to spend one year full-time or two years part-time working in a Crick research group, on a project agreed between the fellow and the Crick group leader.

The scheme aims to:

  • Foster long-term clinical links and collaborations.
  • Provide clinicians with a postdoctoral extension of their research experience, and with scientific networking, training and career development opportunities at the Crick.
  • Provide a platform from which fellows may apply for external funding such as clinician scientist fellowships, to be held at the Crick or elsewhere.

Fellows with their own salary funded via NIHR, universities or other external funding schemes may also apply to be hosted within a Crick research group.

 

Institution/Organisation:
Francis Crick Institute
Application deadline:
External link:
Further information

  

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