The purpose of the post is to recruit a passionate, self-motivated and dynamic postdoctoral Research Associate to join Dr. Dominguez-Villar’s laboratory at Imperial College London, UK. Their research focuses on understanding the molecular mechanisms that maintain human regulatory T cell identity and plasticity and the regulation of CD4+ T cell responses in autoimmune and infectious disease settings.
They have recently defined key signalling pathways underlying human Treg plasticity and acquisition of a Th1-like effector phenotype (Nat Immunol 2018;19:665, Cell Mol Life Sci 2017;74:4059, EMBO Rep 2016;17:1169). The successful candidate will examine the role of specific signalling pathways in maintaining Treg identity and modulating plasticity, and the role of environmental factors in activating/inhibiting them, with application to autoimmune diseases. This is a highly translational research project that will involve human samples from healthy individuals and patients, and might involve in vivo models of autoimmunity. The successful candidate will have a strong human molecular immunology background and experience in human immunology and related techniques. Flow cytometry, culture of primary T cells and Tregs, as well as molecular biology techniques are essential skills for applicants to be considered. Experience with in vivo models of autoimmunity and bioinformatics skills are desired but not required. To find out more about the role, please click on the link below and search by job reference MED00940.