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BSI jobs board

To post a job advertisement on this page, please contact our Education & Careers Officer, Eolan Healy. Note that this service is free to BSI members and their institutions, as well as our corporate members. There is a small charge of £100 for non-members who wish to advertise. 

Please note, all job vacancies are posted as soon as they are received, and are cleared after the closing date, or after three months, if one is not specified.

For more information about the vacancies, please click on the links below. You may also find it helpful to have a look at our funding opportunities page

Current vacancies

PhD: Modulating the microbiota to improve vaccine responses

We are looking for a creative and motivated PhD candidate to join a dynamic, multi-disciplinary research team investigating the early life (infant) microbiota and host interactions. This position is within Dr Lindsay Hall’s lab at the Quadram Institute Bioscience, a new interdisciplinary research institute at the forefront of a new era in gut microbes, food and health research, thus providing an excellent platform for a starting scientific career.

Background: The resident gut microbiota plays an important role in the modulation of both local and systemic immune responses. However, the impact of the microbiome composition on vaccine efficacy remains a limited area of study. Significant differences exist in the induction of vaccine responses in geographically distinct populations, which may be linked to host genetics, nutritional state, exposure to related infectious agents and critically also differences in the resident microbiota. Notably, randomised clinical trials have shown that some probiotic strains, including Bifidobacterium, are able to increase specific immune responses against vaccine antigens. These findings suggest that the presence of specific microbiota members could contribute to a greater vaccine efficacy.

The goal of this PhD studentship is to use microbiology and immunology techniques to identify mechanisms underlying microbiota-vaccination responses and how microbiota therapies may help to augment vaccines responses in different infant cohorts. This studentship represents an excellent training module for a wide range of microbiology, immunology and some bioinformatic techniques utilising pre-clinical and clinical samples.

Institution/Organisation:
University of East Anglia
Application deadline:
Research Assistant - Bioinformatics (Immunology)

Oxford university are seeking a Research Assistant - Bioinformatics (Immunology) to join Professor M Dustin’s lab at the Kennedy Institute of Rheumatology. The focus of Professor M Dustin’s work is on the immunological synapse, integrating its role into the 3D tissue context and translation to treatment of human diseases. You will work on analysing surface proteomics data of human dendritic cells (DCs) maturation and T-cell activation.

You will implement existing and develop new softwares and analyses related to mass-spectrometry-based characterisation of human dendritic cell maturation coupled with transcriptomic analysis of publicly available RNA-seq data. You will manage own research, carefully analyse data and report the results and contribute new ideas to move the project forward. You will implement existing and develop new softwares for analyses of single cell data from automated imaging, flow cytometry and RNA sequencing to identify key differences in T cell response to libraries of proteins presented on supported lipid bilayers based on resting and activated human dendritic cell surface proteomes.

You must hold a Master degree or equivalent in systems/computational biology and have relevant background and knowledge in data analysis and computational/systems biology. You will have programming proficiency using programming/scripting languages such as Python, MATLAB or R, as well as have flexibility and willingness to learn new techniques and methodologies. Excellent English communication and organisational skills and the ability to work independently or as part of a team is essential. Strong interdisciplinary research experiences at the interface systems biology and immunology, as well as experience in mass spectrometry data analysis is desirable.

This is a full-time position fixed-term for 12 months.

Owing to the nature of the research at the Kennedy Institute of Rheumatology, this job will require a satisfactory basic Disclosure and Barring Service check.

Institution/Organisation:
University of Oxford
Application deadline:
Principal Scientist – Antibody Pharmacology

Antibody Pharmacology at GSK comprises a team of 20+ assay scientists, immunologists and biologists who conduct functional assay design, screening and characterisation of potential antibody-based drug molecules. The team is an integral part of the Biopharmaceutical Molecular Discovery organization that is responsible for the discovery of candidate biologics across several Therapeutic Areas including Immuno-oncology, Respiratory, Immuno-Inflammation and Infectious Diseases.

They are seeking an experienced laboratory scientist with a deep understanding of antibody structure and function relationships, and in particular the contribution of Fc biology to the Mechanism of Action and PK/PD of an antibody.  The candidate will be expected to act as a Subject Matter Expert (SME) in Fc biology and be accountable for profiling Fc functions and selecting the most suitable Fc variant that produces the desired Fc functionality. 

Depending on experience,  the candidate may be responsible for leading and driving a Fc biology matrix team in designing novel in vitro assays that are disease relevant, and standardizing assays to accelerate the discovery process.

Key responsibilities:
•    Demonstrate scientific leadership through acting as a Subject Matter Expert in Fc biology; Stay abreast of the latest literature and developments in the field; Be accountable for selecting the most suitable Fc variant that produces the desired Fc functionality
•    Collaborate with other functions within GSK R&D, especially Antibody Technology and Translational Science; Devise and implement a Fc biology strategy that supports the discovery and development of best-in-class antibody drug candidates 
•    Influence Drug Discovery Project Teams as an Antibody Pharmacology SME. Accountable for designing and conducting disease relevant functional assays and Fc biology assays; Deliver timely quality data packages that enable project decision-making and progression
•    When suitable, participate in relevant technology projects that optimise/modernise the antibody drug discovery process
•    Be able to publish and present both internally and externally

On offer is a collaborative learning environment and the opportunity to develop your career and gain experience across drug discovery. If you share the priorities of innovation, performance and trust and are motivated to contribute towards bringing lifesaving drugs to patients, then we'd love to hear from you.

Institution/Organisation:
GlaxoSmithKline (GSK)
Application deadline:
Research Technician

St. George's, University of London are looking to appoint an exceptional and enthusiastic individual to join the new Group B Streptococcal laboratory. The post holder will be responsible for the day to day running of the flow cytometry cellular work and will play a pivotal role in assay development to good laboratory practice standards. They would like to hear from candidates with previous experience working with functional assays, flow cytometry and cell culture who are keen to progress their skills in a University setting.

The successful candidate will be able to work accurately with good attention to detail, have excellent inter-personal skills and be able to organise and prioritise their work in a high throughput environment. Experience of working to GCLP standards would be an advantage.

Flexible working, including part-time or reduced hours of work, opportunities to work from home for many posts, compressed hours and local flexibility in agreeing start and finish times of work are among the extra benefits offered by St George’s, University of London.

Institution/Organisation:
St. George's, University of London
Application deadline:
PhD studentship in Applied Vaccinology

An unique opportunity is available to pursue a GSK funded PhD studentship within the Host Pathogen Research Group at the school of Biochemistry and Immunology at Trinity College Dublin (TCD), in collaboration with GSK Vaccines, Siena. The chosen candidate will have the unprecedented opportunity to obtain a PhD from Ireland’s premier research University while training in applied immunological research at the worlds largest vaccine research company, thus equipping the individual with a unique skill set to pursue a successful research career within industry or academia.

The student will join a multidisciplinary team of academic and industrial immunology researchers investigating Staphylococcus aureus immunity. S. aureus is the leading cause of skin and soft tissue infections (SSTI), which are common, frequently recurrent and often caused by antibiotic-resistant strains. In addition, SSTI are a primary entry portal for invasive infection. Therefore, a vaccine that protects against S. aureus SSTI is a major medical need. Human skin contains twice as many T cells than blood. Skin-resident memory T cells (TSRM) permanently reside in the skin forming the first line of adaptive immunity against re-infection. The goal of this project is to assess the role of TSRM in protection against primary and recurrent S. aureus SSTI and how vaccination can exploit this response. The ability of different adjuvants to modulate the TSRM response will be also evaluated.

This PhD project will utilize an in vitro model of human skin explant and an in vivo murine model of recurrent SSTI. The student will acquire technical expertise in human and mouse immunology, microbiology, confocal microscopy and immunohistochemistry, human skin explants, adjuvants and formulation science.

The studentship will be for 4 years and the successful applicant will be expected to have a first class honors degree or a high upper second in a biological subject (preferably with a significant immunology component). The student will be based primarily at the GSK Vaccine Research Campus in Siena, Italy where they will join an established group of PhD students as part of the Vaccine Academy. They will work under the direction of the company supervisor Dr Elisabetta Soldaini, PhD, Senior Scientist in the Preclinical Evidence Generation – Immunology Function at the Research Center of GSK.

Institution/Organisation:
Trinity College Dublin
Application deadline:
MRC Programme Leader - Immunology

The MRC Toxicology Unit is a leading International Research Institute within the School of Biological Sciences, University of Cambridge. The Unit delivers high impact mechanistic toxicology research, pursuing hypothesis-driven toxicological questions with a particular focus on the study of the causal links between exposure to endogenous and exogenous toxicants, molecular initiating events and adverse outcome pathways.  The Unit's overall aims are to carry out pioneering research which leads to improved health and to train and mentor the next generation of toxicologists. The research environment provides state-of-the-art research facilities including microscopy, Cryo-EM, flow cytometry, proteomics, bioinformatics and imaging. 

They are seeking to recruit a Programme Leader, at Director of Research level, to the Unit's new Inflammatory Responses and Immune Regulation theme. They would be particularly interested in research programmes which include the study of adverse effects on the immune system resulting from therapeutic exposure to biologics, e.g. immune modulators and CAR- T cells, adverse immune responses to chemicals and environmental agents including respiratory tract allergies or autoimmunity, although other areas relevant to immuno-toxicology will be considered. The position comes with an attractive research funding package, including core-funded postdoctoral posts and PhD studentships.

As Director of Research you will develop the scientific strategy for your research programme and contribute to the strategic direction of the Unit. Leading a team of researchers and students you will contribute to the advancement of knowledge in your research subject, maintain a successful programme of funding; collaborate externally and internally to advance thinking and disseminate your research in international papers and at international conferences.

Applicants must have a PhD and an international reputation within their field; they will have led original research in a relevant area and be able to build effective and sustainable international collaborative partnerships. They will have the vision, experience and enthusiasm to build on current strengths within the Unit as well as an established track record in attracting research grant support.

This is an open-ended position funded by the Medical Research Council, renewable every 5 years.
 

Institution/Organisation:
University of Cambridge
Application deadline:
Lecturer in Immunology (E&R)

Following a recent major award, our Diabetes Centre of Excellence is expanding substantially.

This permanent, full time or part time post is available at the University of Exeter Medical School, College of Medicine & Health, based in Exeter.

Summary of the role

The post holder will lead a dynamic research group which will develop ideas, secure funding and deliver innovative research projects, they will supervise and enthuse undergraduate and postgraduate students in research and excel at teaching. The post holder will produce research outputs at an appropriate level and disseminate their research to academic, healthcare and patient communities. Collaboration with other colleagues in the College of Medicine and Health, the Living Systems Institute, Centre for Medical Mycology and Institute for Data Science and Artificial Intelligence is very much encouraged as is the development of external national and international collaborations.

Applications from specialists in Immunology are very welcome. The immunologists will be able to work on novel and pioneering approaches using unique human pancreas samples obtained at the time of diagnosis of type 1 diabetes. The ultimate aim is to understand the underlying disease processes in order to stimulate the development and application of novel immunotherapies and inform the design of new clinical trials.  The availability of our new high-resolution, automated, digital pathology system will support this work by superseding current more laborious methods of image analysis.  Interdisciplinary work will be with our Living Systems Institute.

A particular interest in individuals who:

will bring their leadership, tools and skills and contribute their expertise to this diabetes research in the areas of Bayesian Statistics, Artificial Intelligence, Immunology and Cell Biology
and have educational strengths in the above areas
Applications welcome from individuals who have the skills described above but who have not, as yet, applied those skills to diabetes research but are keen to do so, as well as those already working in diabetes and its associated conditions.

Institution/Organisation:
University of Exeter
Application deadline:
Research Associate

An exciting opportunity has arisen for a Research Associate to make a leading contribution to the Breast Cancer Now-funded project: “Evaluation of metabotropic glutamate receptor 3 (mGluR3) as a therapeutic target in breast cancer”. The goal of this project is to investigate how targeting mGluR3 could have therapeutic benefit whilst exploring the fundamental mechanisms by which glutamate regulates breast cancer metastasis. The project will deploy geneticallyengineered preclinical models, pharmacological inhibition, and advanced imaging, metabolomic and immunological techniques to characterise events in metastatic target organs such as reshaping of the immune cell microenvironment and remodelling of the stroma and tissue architecture. The post-holder will be supervised by Dr Iain Macpherson and situated in Professor Norman’s laboratory at the CRUK Beatson Institute and this post has funding for 3 years in the first instance.

Institution/Organisation:
University of Glasgow
Application deadline:
Ongoing
Post-Doctoral Scientist

This is an exciting opportunity for a post-doctoral scientist to perform laboratory research on the development of new assays for the assessment of Group B Streptococcal immunity at St George’s, University of London (SGUL).The principal role of the post holder will be to undertake research in mucosal immunity to GBS, helping to advance a high-level research programme in the laboratory of Dr. Le Doare, and in close collaboration with Prof Heath, Vaccine Institute Director. The scientist will have the opportunity to develop a programme of high-level academic research in collaboration and interaction with Harvard University, USA. The post holder will have a strong interest in immunology and/or infection and experience of scientific data handling. He or she will also participate in the other clinical and research activities linked to the PIDRG and the St George’s Vaccine Institute. The post is funded for one year in the first instance, but may be renewable.

Flexible working, including part-time or reduced hours of work, opportunities to work from home for many posts, compressed hours and local flexibility in agreeing start and finish times of work are among the extra benefits offered by St George’s, University of London.

Institution/Organisation:
St. George's, University of London
Application deadline:
Lecturer (Academic) in Immunology

You will be based in the Department of Life and Environmental Sciences, within the Faculty of Science and Technology. This interdisciplinary department comprises over 35 staff with diverse teaching and research expertise embracing biomedical sciences, forensic science, bioinformatics, geoinformatics, genetics, evolution, ecology and environmental science. This is an opportunity to join a growing department, which has seen significant investment in physical and staff resources.

You will coordinate and deliver research-informed teaching on units such as Introduction to Immunology (1st year), Advanced Immunology (2nd year), Epidemiology and Infection (3rd year) and Pathophysiology (3rd year), taken by students on programmes including BSc Biomedical Sciences, BSc Medical Science and BSc Biological Sciences.

Working with colleagues you will develop and enhance the profile of biomedical science teaching and research, supervise students from first year to PhD level, be involved in laboratory classes, unit administration and research activities.

This appointment is part of a strategic investment in the research and teaching of medical sciences at Bournemouth University. You will be qualified to Doctorate level or be able to demonstrate the ability to create and disseminate knowledge at an equivalent level and the capability to convert this knowledge into a doctorate in a maximum of 3-5 years from the date of appointment. You will be research active and committed to a culture of academic excellence and continuous improvement.

Institution/Organisation:
University of Bournemouth
Application deadline:

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