BSI jobs board

The role:
Nexus BioQuest are looking for a collaborative, enthusiastic Principal Scientist to join our growing company. You will have some experience of confocal imaging and image analysis, use of a high content imaging system would be a plus. You will manage a small team running diverse client projects, and be involved at all stages from inception and planning, running experiments and reporting and presenting data to clients.
The role will involve some laboratory work so problem solving skills at the bench and a passion for mentoring, training and providing scientific guidance to more junior staff is a must. You should be a good communicator and keen to work in a team environment to bring projects to completion. Experience of line management is required for this role. There, will be a significant opportunity for you to grow both your management and scientific skill set and knowledge within the immunology space.

Who you are:
You should have a passion for working in immunology in the drug development industry. You should be interested in not just the science but also managing and developing people, as you will be managing a small team of dynamic and talented scientists and senior scientists. The role is suited to someone who enjoys diversity and working on varied projects and is able to work to fixed timelines. You should be able to demonstrate that you have previously provided line management. You should have a very strong fundamental knowledge of the immune system and hold an MSc or PhD which involved study of some aspect of the immune system. Ideally you will have 6 years or more post-doctoral or equivalent industry experience. You should be rigorous in your approach to data handling, analysis and presentation.
You should have experience in confocal imaging and image analysis, experience of high content imaging would be a plus.
Significant practical experience in one of more of the following areas is also required:
•    Cell culture of primary immune cells and cell lines
•    Flow cytometry
•    Imaging and image analysis
•    qPCR/molecular biology
•    Cytokine analysis (multiplexing or ELISpot)
If you are passionate about the immune system and how it can be targeted to provide therapeutic solutions, love diversity of research, enjoy communicating and enjoy working in a collaborative and innovative environment please apply to join our team by sending your CV to: team@nexusbioquest.com

The role:
Nexus BioQuest are looking for a collaborative, enthusiastic Senior Scientist to join our growing company. You will work within a small team to run diverse client projects, and be involved at all stages from inception and planning, running experiments and reporting and presenting data to clients. A significant part of the role will be laboratory work so problem solving skills and a passion for being at the bench and analysing data is a must. You should be a good communicator and keen to work in a team environment to bring projects to completion. The role will involve providing mentorship to more junior scientists and give you the opportunity to acquire management skills. There, will be a significant opportunity for you to grow your skill set and knowledge within the immunology space.
Who you are:
You should have a passion for working in immunology in the drug development industry. The role is suited to someone who enjoys diversity and working on varied projects. You should have a very strong fundamental knowledge of the immune system and hold an MSc or PhD which involved study of some aspect of the immune system. Ideally you will have 3years or more post-doctoral or equivalent industry experience. You should be rigorous in your approach to data handling, analysis and presentation. Significant practical experience in one of more of the following areas is required:
•    Cell culture of primary immune cells and cell lines
•    Flow cytometry
•    Imaging and image analysis
•    qPCR/molecular biology
•    Cytokine analysis (multiplexing)
If you are passionate about the immune system and how it can be targeted to provide therapeutic solutions, love diversity of research, enjoy communicating and enjoy working in a collaborative and innovative environment please apply to join our team by sending your CV to: team@nexusbioquest.com

The role:
Nexus BioQuest are looking for a collaborative, enthusiastic scientist to join our growing company. You will work within a small team to run diverse client projects, and be involved at all stages from planning, running experiments and reporting. A significant part of the role will be laboratory work, so problem solving skills and a passion for being at the bench and analysing data is a must. You should be a good communicator and keen to work in a team environment to bring projects to completion.
There, will be a significant opportunity for you to grow your skill set and knowledge within the immunology space working within an inclusive small team environment.
Who you are:
You should have a passion for working in immunology in the drug development industry. The role is suited to someone who enjoys diversity and working on varied projects. You should have a strong fundamental knowledge of the immune system and hold an MSc which involved study of some aspect of the immune system. The role could also be suited to a talented BSc student who’s degree focused on immunology and who has some experience working in a laboratory environment. You should be rigorous in your approach to data handling, analysis and presentation. Practical experience in one or more of the following areas is required:
•    Cell culture of primary immune cells and cell lines
•    Flow cytometry
•    Imaging and image analysis
•    qPCR/molecular biology
•    Cytokine analysis (multiplexing)
If you are passionate about the immune system and how it can be targeted to provide therapeutic solutions, love diversity of research, enjoy communicating and enjoy working in a collaborative and innovative environment please apply to join our team by sending your CV to: team@nexusbioquest.com

The BSI internship scheme offers three-month internships to graduates interested in exploring the career possibilities available within learned societies. The internship will allow you to learn more about the activities that the Society undertakes, with a particular focus on our public engagement work.  This internship scheme is open to candidates who are BBSRC-funded PhD students looking to undertake a ‘Professional Internship for PhD students (PIPS)’ as part of their Doctoral Training Programme within the life sciences. 

We are looking for graduates with good organisational skills who are willing to undertake a range of diverse tasks. During the three months of the internship you will be engaged in primarily helping the British Society for Immunology to drive forward our public engagement work, particularly around vaccines.  The exact project undertaken during the internship will depend on the individual candidate but will involve working with the BSI team to:

• Carry out a public engagement project with the help of staff, on a topic to be decided. This will require being able to translate complex immunology to be easily understood by a public audience.  The output of this project will be disseminated, as appropriate, to the public and BSI members, as well as leading partners and external organisations.
• Assist with additional activities that contribute to the overall running of the BSI. This could include activities such as supporting our in-house journal teams with their commissioning and marketing work, contributing to the BSI's wider communications and partnership work.

Job description

The Gwyer Findlay lab investigates how neutrophils affect T cell phenotype. Their work sits at the interface of immunology and inflammation biology and they use a variety of methods in their studies – immunology, molecular biology, computational biology and imaging.

In this project they are aiming to understand how neutrophils alter T cell cytokine production. They have previously shown that when neutrophils release antimicrobial peptides, they enter nearby T cells and profoundly alter T cell cytokine production. In particular, they affect the production of the IL-17 family of cytokines. In this project they will work out how this occurs. Through culture of mouse and human T cells, flow cytometry, RNA and ATAC sequencing and imaging, they will examine the signalling pathways induced by neutrophil peptides and how they lead to differential IL-17 production.

You will hold a PhD in immunology, biology, or a related discipline.  Highly organised and driven, you will demonstrate initiative and problem-solving skills. You will have experience in and knowledge of T cell immunology, cell culture, and flow cytometry.

Applications will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification.  The title of Research Fellow will be applied upon completion of PhD.  Prior to the qualification being awarded the title of Senior Research Assistant will be given.

What they can offer you

• a world-class research environment
• access to mentoring, career development and networking across the University and beyond
• a personalised training and development plan including external training courses and attendance at conferences
• a friendly, supportive lab environment

Professor Sarosh Irani (currently at Oxford University) has been recruited to the Mayo Clinic, Florida and is looking for pre- and post-doctoral immunologists to help develop his translational neuroimmunology research program. 
The overall aim of the work is to characterise multicompartmental autoantigen-reactive T and B cells in neuroimmunological diseases of the central nervous system, building on their recent findings. 

Researchers with skillsets including basic and advanced flow cytometry / cell sorting, lymphocyte cultures and molecular biology including experience with scRNA-seq and PCRs are invited to share their CVs and a statement of interest.
Another 5 members of the current laboratory team will join him in Mayo, so there are plenty of opportunities to learn about and develop their current neuroimmunology platforms. In addition, there will be several junior researchers to mentor and involvement in grant writing is very welcomed.

This is a fantastic opportunity to join a well-funded research group at Mayo Clinic, a centre that very much values its staff. An added bonus is that weekends could be spent in the beautiful beach resort of Jacksonville and the surrounding natural habitats.
If you’d like more information, please contact Sarosh directly: sarosh.irani@ndcn.ox.ac.uk

Applications are invited for a full-time, 4-year postdoctoral Cell Biologist on Crick terms and conditions of employment. Please note this is a rolling advert with no specific closing date, which will close once the position is filled. Applications will be considered as they arrive.

The Tybulewicz group - Immune Cell Biology Laboratory

The lab is studying signalling pathways that control the biology of B and T lymphocytes. In particular we are working on pathways that control lymphocyte activation, differentiation, survival, adhesion and migration. We use a broad range of techniques including cell biology, mouse genetics, biochemistry, imaging, proteomics, transcriptomics and cellular immunology. The lab currently consists of around 13 researchers including PhD students, postdocs and laboratory research scientists. For more information see the lab website.

Project summary

We have previously shown that the WNK1 kinase regulates T cell migration and adhesion (Köchl et al, 2016. Nat Immunol, 17, 1075-1083). In unpublished work we have found that WNK1 also regulates T cell activation and discovered a novel and unexpected signalling pathway that regulates ion and water flux across the plasma membrane, which is essential for T cell migration and activation, thereby opening up an exciting new area of investigation. The proposed research will focus on how the WNK1 pathway and ion and water flux regulate T cell migration and activation. The work will look at the role of ion and water transporters in the regulation of these processes, and is likely to use cell biology, imaging, mouse genetics, biochemistry, microfluidics and optogenetics.

Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.

Informal enquiries are welcome, and should be directed to Victor Tybulewicz (Victor.T@crick.ac.uk).

Key experience and competencies
The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:

Essential

• PhD, or in the final stages of PhD completion, in a relevant area (including but not limited to: cell biology, biochemistry, genetics)
• Knowledge and experience of cell biology
• Experience of subcellular imaging using light microscopy techniques, such as TIRF, super-resolution and time-lapse imaging.
• Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals
• Evidence of data presentation at scientific meetings
• Excellent organisational and communication skills
• Ability to work independently and also capable of interacting within a group

Desirable

• Experience in research using mouse genetics or biochemistry
• Experience in research on T or B cells

Job Summary

As a Technical Application Scientist at BioLegend, you will be a customer’s primary point of contact for technology, products, and, services. You will represent the company locally for both technical and pre-sales support as well as facilitate scientific collaboration. The main efforts to build customer relationships will be through in-person or virtual consultation with individual customers with respect to their projects & needs, provide education on relevant new technologies, assist in technical support, and conduct field marketing initiatives through seminars and presentations. Your responsibility is to interphase between the customer and BioLegend to enable researcher success and facilitate discovery.

This position will require frequent local travel and will be responsible for support of the regional Academic research institutions and Biotech/Pharma companies in Cambridge (East Anglia) & Norfolk area. Primary work location will be in Cambridgeshire (East Anglia).

In this role, you are responsible for building relationships with scientists within a defined territory. This position is responsible for both the scientific success of key accounts. Flexibility and proactivity are crucial to success in this remote; field-based position. You will be supported and collaborate with a team of experienced field technical experts and sales support personnel. This job carries direct sales responsibilities; however, priority is given to the technical and scientific side of the role. 

Essential Functions

• Develop relationships, both in person and remote, with key customers at assigned focus accounts.
• Conduct and present technical seminars to labs, user groups, and local meetings.
• Coordinate and perform product demonstrations, trainings, and, technical support.
• Provide direct sales support to customers in collaboration with team leader & Global Sales Operations team.
• Contribute to local business development related to product development, licensing, service/collaborative agreements, and, other responsibilities as needed.
• Represent BioLegend at user group meetings, scientific conferences, and local shows.
• Maintain a contact database in customer retention management system (Salesforce)
• Manage expenses through monthly reports.
• Prepare quarterly reports on territory performance, and, notable business developments at key accounts.
• Reporting any activity related to competitor activities, or, business opportunities as applicable.
• Communicate needs for self-development and develop long term professional goals.
• Travel required as necessary (some overnight travel for international events/training at HQ, but frequent local travel within Cambridge (East Anglia) & Norfolk areas.

About the study

Imperial College London are trying to understand why some people make a full recovery after COVID-19 while others go on to develop long-term symptoms. To do this, they are looking for volunteers to help them do research into the immune response following infection.

This is part of the Long Covid research programme funded by the National Institute of Health Research (NIHR).

Eligibility
They are looking for people in any of these groups:

• Never had COVID-19 but have received COVID-19 vaccine doses
• Had COVID-19 and made a full recovery within 4 weeks (and may have since received vaccine doses)
• Had COVID-19 and have since suffered from the long-term symptoms described as Long Covid. These may include fatigue, ‘brain fog’, exhaustion when walking, breathlessness, chest pain and other persistent symptoms

How the study works
They will email you a short questionnaire and ask you to return it to them for analysis. They will then invite people showing specific sets of symptoms to pay a visit to the Hammersmith Hospital Campus where they will take a small blood test (about the size of an egg cup of blood). This will be taken to their lab for analysis of immunity to the virus and other features of immune function, including autoimmunity and immune cell subsets. They may invite you for a repeat test around 4 months later. They may also ask you to donate a stool sample, allowing them to look for any evidence of persistent virus.

How to participate
If you might be interested in taking part please contact the investigator, Professor Danny Altmann: altmannlongcovidstudy@imperial.ac.uk.

The Francis Crick Institute is breaking down barriers between basic and clinical research by supporting collaboration and the sharing of ideas, bringing more clinical expertise to the Crick and offering truly interdisciplinary training to scientists and clinicians.

Together with their partners, this helps them achieve their aim of creating the scientific leaders of the future and accelerates the movement of research ideas out of the lab and into clinical practice.

To ensure that ther clinicians can maintain links to clinical training and receive clinical mentorship, clinical fellows may be associated with external partners. 

This could be with one of their partner universities (University College London, Imperial College London and King's College London), with other universities, or with NIHR biomedical research centres and Cancer Research UK (CRUK) centres.

They're also part of the CRUK City of London Centre, which offers multidisciplinary cancer-based doctoral clinical fellowships as part of its training programme. 

Eligibility

• They are looking for talented and motivated postdoctoral clinical fellows who are passionate about research and show outstanding potential for continuing a career in academic medicine.
• Applicants should have completed a medical degree, or equivalent clinical professional qualification, and hold, or be about to hold, a research PhD.
• Applications are welcome from all medical and surgical specialties.