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Job description
This post will based in the Inflammation Biology Group headed by Prof. Toby Lawrence at the Centre for Inflammation Biology & Cancer Immunology (CIBCI) and in close collaboration with the Systems Cancer Immunology Group headed by Dr. Shahram Kordasti, both based at Guy’s Hospital campus. CIBCI aims to leverage expertise in inflammation biology to extend fundamental and applied knowledge of tumour immunobiology. In this context, the post holder will develop projects applying novel work flows and analytical pipelines for the acquisition of multidimensional data sets, including single cell RNA sequencing, imaging mass cytometry and spatial transcriptomics, from both patient samples and experimental models, with the ultimate goal of deconstructing the roles of myeloid cells in the tumour immune-microenvrionment and their bearing on cancer using functional genomics. The post holder will also be involved in the training and supervision of PhD students and junior research associates involved in related projects.
This post will be offered on a 3 years fixed-term contract with the possibility to extend for a further 2 years
This is a full-time post

Key responsibilities

• To work on the immunological and molecular profiling of patient samples and tissues from animal models and patients.   
• To develop mechanistic insights derived from such profiling activities in collaboration with clinical and basic scientists 
• To use a variety of technologies to investigate the functional immunological status of cancers and the influence of their microenvironments  
• To create, implement and use analytical and bioinformatics tools to analyse and interpret multidimensional data. 
•  To establish the pipelines for collection and analysis of patient samples and enable the development of experimental protocols.
• More on the main job advert page 

The British Society for Immunology is looking for a full-time, permanent Editorial Coordinator with a strong understanding and passion for science and Open Access publishing.

As an integral member of our team, the role-holder will be responsible for the management of the peer review system for the three Society journals, supporting the Editors in the handling and processing of incoming manuscripts. The Editorial Coordinator will also be required to assist in the implementation of the journal strategies, including managing commissioned articles and review series, recruiting and onboarding Editorial board members, and identifying areas for improvement within the peer review process. 

This varied and fast-paced role is ideally suited to a proactive and organised individual who is passionate about science and has a keen interest in building their experience in Open Access academic publishing.

The successful applicant will be able to develop further in their career as part of a fun, hardworking and extremely ambitious team.

A postdoctoral position in Immunology is available at the Immunophysiopathology of Infectious Diseases Department at the Institut Pasteur de Dakar, under the supervision of Dr Inès Vigan-Womas. 

This multidisciplinary project will combine local pathogen sequencing surveillance and clinical epidemiology with local immunological understanding and tools in order to speed up the discovery of new diagnostic tools and new vaccine candidates. The immunological studies will extend to the rapid discovery of novel monoclonal antibodies against VoCs that are critical tools for probing protein structure, key reagents for differentiating variant proteins, and potential therapeutic monoclonal antibody drugs. The applicant will benefit from the multidisciplinary research environment, infrastructure and platforms provided by the Institut Pasteur de Dakar. He/she will participate actively to the development of the immunological platform and tools. He/she will join a collaborative international project involving partners within and beyond campus.

Candidate qualification and selection criteria: They are seeking highly motivated, creative, dynamic and enthusiastic postdoctoral fellows, able to work independently and to supervise PhD student and Masters, with excellent communication skills. Applicants should have a Ph.D. in immunology. This project will require a wide variety of techniques including multi-parametric flow cytometry, B and Tcells stimulation/ImmunoSpot, cell sorting, single cell molecular profile analyses and B-cell receptor repertoire analyses applied to the study of human cohorts. Extensive experiences in immunological and molecular techniques are essential.

Application: Candidates should send their application including CV, a brief description of research accomplishments, list of publications, cover letter and contact for at least two referees into a single PDF file to Inès VIGAN-WOMAS (Ines.vigan.womas@pasteur.sn, ivigan@pasteur.fr). Selected candidates will be contacted for video interview.

F Star Therapeutics have an exciting opportunity for a Scientist to join F-star’s Translational Development team to support our early development biomarkers strategy through the exploration, integration, interpretation and reporting of results of multivariate clinical pharmacology data e.g., PK,PD data. 

You will work as part of multi-disciplinary project teams comprising clinical operational, translational medicine, medical and project management to advance clinical development of F-star drug candidates.  

Responsibilities include: 

• Work with project team(s) to develop programme specific clinical biomarker / clinical pharmacology strategy that help drive F-star’s clinical development decisions.
• Project lead for implementation of clinical biomarker plans and supporting analytical endpoints (e.g., cellular and soluble biomarker assays using flow cytometry and ligand binding platforms such as MSD, Gyros, multi-colour flow cytometry, IHC etc).
• Work with matrix team to develop outsourcing plans for clinical biomarker assay types/platforms/data types and work within the clinical and translational sub teams to analyse and interpret the biomarker in the context of emerging clinical data from our and others’ trials.
• Provide technical oversight and direction for development of assays to meet performance requirements.
• Ensure experiments and data management activities result in robust, quality data to inform decision making on projects.
• Carry out analyses of data to identify issues and implement necessary changes.
• Lead clinical pharmacology data analysis ensuring timely data interpretation and delivery to support project development milestones.
• Support best practice and be aware of regulatory guidelines with a view to transferring methods into a regulated environment to be used under appropriate GxP quality standards e.g., GLP, GcLP, GCP.
• Generate and review presentations for project team meetings, collaborators, and governance teams. When necessary, communicate research results through conference presentations, scientific publications, or project reports (including documents for regulatory submission).
• Work with Bioanalytical and Biomarker outsourcing manager and technical specialists to develop own understanding and provide project and translational context to those individuals.
• Support patent filings where appropriate.
• Read scientific literature and keep up with the new trends and techniques related to role.

About you: 

• Prior experience in Immunology and translational research in academic or industry settings, with a PhD in a biological subject with relevant focus on cell biology or immunology or, equivalent industry experience. 
• Proven assay development experience and proficiency in a range of assay formats (at least 3 of the following: immunoassays, matrix biomarker assessment, protein analysis by mass spectrometry, multi-colour flow cytometry, Immunohistochemistry, transcriptomics).
• Ability to visualize and interpret data, with a solid understanding of statistics as it applies to bioassays.
• Experience in maintaining quality during multiple ongoing experiments.
• Previous hands-on experience in handling clinical and/or human biological samples.
• Excellent communication and presentation skills with proven ability to work well in cross-functional matrix teams and interact with outside vendors, consultants and collaborators.
• Proficient in designing and optimising biological experiments and/or immunological assays for robustness and reliable data quality, interpretation of data and trouble shooting. 
• Extensive experience in record keeping, data recording and understanding of factors affecting assay robustness and levels of data quality.
• Ability to work unsupervised and organised with strong attention to detail.