Therapeutic tolerance

Immunotherapy Advances journal

Led by Professor John Isaacs (Newcastle University)

Coming out of the 5th International Therapeutic Tolerance Workshop, this Special Collection in Immunotherapy Advances focuses on advances at the cutting edge of clinical therapeutic tolerance and progress in developing tolerogenic interventions.

Figure showing Treg-mediated suppressive mechanisms and cell fates of responder T cells subjected to suppression
Figure from 'Treg-based immunotherapy for antigen-specific immune suppression and stable tolerance induction: a perspective'

REVIEW

Treg-based immunotherapy for antigen-specific immune suppression and stable tolerance induction: a perspective

Shimon Sakaguchi, Ryoji Kawakami, Norihisa Mikami

Figure showing mechanisms by which lymphohematopioetic GVHR (LGVHR) may promote tolerance to allografts and reverse autoimmunity
Figure from 'Leveraging the lymphohematopoietic graft-versus-host reaction (LGVHR) to achieve allograft tolerance and restore self tolerance with minimal toxicity'

REVIEW

Leveraging the lymphohematopoietic graft-versus-host reaction (LGVHR) to achieve allograft tolerance and restore self tolerance with minimal toxicity

Megan Sykes

REVIEW

Challenges in tolerogenic dendritic cell therapy for autoimmune diseases: the route of administration

María José Mansilla, Catharien M U Hilkens, Eva M Martínez-Cáceres

Figure depicting the cancer-immunity cycle
Figure from 'Combination therapies for the optimisation of bispecific T-cell engagers in cancer treatment'

REVIEW

Combination therapies for the optimisation of bispecific T-cell engagers in cancer treatment

Winston M Zhu, Mark R Middleton

Figure illustrates the two major ways for prevention of RA
Figure from 'Prevention vs treatment of rheumatoid arthritis'

REVIEW

Prevention vs treatment of rheumatoid arthritis

Lars Klareskog, Lars Alfredsson