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Cancer immunology and immunotherapy Virtual Issue

In celebration of World Cancer Day 2023 the British Society for Immunology is pleased to collect together recent articles from our official journals Clinical & Experimental Immunology, Discovery Immunology and Immunotherapy Advances which highlight cutting-edge research into cancer immunology and immunotherapy.

Knowledge of the mechanisms by which the immune system interacts with cancer as it develops is increasing rapidly. From this field, cancer immunotherapy has emerged as one of the most exciting and promising approaches to treating cancer. These developments have translated into medical breakthroughs for many cancer patients, although the high prevalence of non-responders and adverse reactions reveals that there are still significant challenges to overcome.

This collection features research and reviews on key topics in the field topics such as CAR-T cell therapies, antibody biomarkers, adverse events and new drug mechanisms. All articles are free to read online.

We hope you enjoy reading this collection of articles and we encourage you to share this using the hashtag #WorldCancerDay and looping in @CEIjournal, @discovimmunol and @IMTadvances.

Clinical & Experimental Immunology, Immunotherapy Advances and Discovery Immunology are the official journals of the British Society for Immunology. Profits derived from the sale of the journals are invested back into the BSI, providing major financial support for the Society's activities. Support the journals and the Society by considering the journals for your next submission! 

Figure from 'Antibodies as biomarkers for cancer risk: a systematic review'
Figure from 'Antibodies as biomarkers for cancer risk: a systematic review'

Clinical & Experimental Immunology

Research article

Immune checkpoint inhibitors and cellular treatment for lymphoma immunotherapy

F Li, Y Chen, M Pang, P Yang, H Jing

Review

Antibodies as biomarkers for cancer risk: a systematic review

Maria J Monroy-Iglesias, Silvia Crescioli, Kerri Beckmann, Nga Le, Sophia N Karagiannis, Mieke Van Hemelrijck, Aida Santaolalla

Review

Immunotherapeutic targeting of activating natural killer cell receptors and their ligands in cancer

Matthias Peipp, Katja Klausz, Ammelie Svea Boje, Tobias Zeller, Stefan Zielonka, Christian Kellner

Research article

Panobinostat enhances NK cell cytotoxicity in soft tissue sarcoma

Xiuxia Lu, Mengmeng Liu, Jing Yang, Yi Que, Xing Zhang

Review

Does CCL19 act as a double-edged sword in cancer development?

Arezoo Gowhari Shabgah, Zaid Mahdi Jaber Al-Obaidi, Heshu Sulaiman Rahman, Walid Kamal Abdelbasset, Wanich Suksatan, Dmitry O Bokov, Lakshmi Thangavelu, Abduladheem Turki Jalil, Farhad Jadidi-Niaragh, Hamed Mohammadi, Kazem Mashayekhi, Jamshid Gholizadeh Navashenaq

Figure from article 'What do cancer-specific T cells ‘see’?'
Figure from article 'What do cancer-specific T cells ‘see’?'

Discovery Immunology

Review

What do cancer-specific T cells ‘see’?

Sabaria Shah, Abdullah Al-Omari, Katherine W Cook, Samantha J Paston, Lindy G Durrant, Victoria A Brentville

Research article

NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression

Sophie Curio, Sarah C Edwards, Toshiyasu Suzuki, Jenny McGovern, Chiara Triulzi, Nagisa Yoshida, Gustav Jonsson, Teresa Glauner, Damiano Rami, Robert Wiesheu, Anna Kilbey, Rachel Violet Purcell, Seth B Coffelt, Nadia Guerra

Figure from 'Characterization of sabatolimab, a novel immunotherapy with immuno-myeloid activity directed against TIM-3 receptor'
Figure from 'Characterization of sabatolimab, a novel immunotherapy with immuno-myeloid activity directed against TIM-3 receptor'

​Immunotherapy Advances

Review

Balancing the good and the bad: controlling immune-related adverse events versus anti-tumor responses in cancer patients treated with immune checkpoint inhibitors

Guilherme Ferreira de Britto Evangelista, Amanda Braga Figueiredo, Milton José de Barros e Silva, Kenneth J Gollob

Research article

Characterization of sabatolimab, a novel immunotherapy with immuno-myeloid activity directed against TIM-3 receptor

Stephanie Schwartz, Nidhi Patel, Tyler Longmire, Pushpa Jayaraman, Xiaomo Jiang, Hongbo Lu, Lisa Baker, Janelle Velez, Radha Ramesh, Anne-Sophie Wavreille, Melanie Verneret, Hong Fan, Tiancen Hu, Fangmin Xu, John Taraszka, Marc Pelletier, Joy Miyashiro, Mikael Rinne, Glenn Dranoff, Catherine Sabatos-Peyton, Viviana Cremasco

Review

An overview of CAR T-cell clinical trial activity to 2021

Antonella Adami & John Maher

Review

A glutamine ‘tug-of-war’: targets to manipulate glutamine metabolism for cancer immunotherapy

Laura J Pallett, Sarah Dimeloe, Linda V Sinclair, Adam J Byrne, Anna Schurich

Research article

Type 2 immunity is maintained during cancer-associated adipose tissue wasting

Patrick J Lenehan, Assunta Cirella, Amiko M Uchida, Stephanie J Crowley, Tatyana Sharova, Genevieve Boland, Michael Dougan, Stephanie K Dougan & Max Heckler

Clinical & Experimental Immunology, Immunotherapy Advances and Discovery Immunology are the official journals of the British Society for Immunology. Profits derived from the sale of the journals are invested back into the BSI, providing major financial support for the Society's activities.

Support the BSI, submit your work now: