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Cancer immunology and immunotherapy Virtual Issue

In celebration of World Cancer Day the British Society for Immunology is pleased to collect together recent articles from our official journals Clinical & Experimental Immunology, Discovery Immunology and Immunotherapy Advances which highlight cutting-edge research into cancer immunology and immunotherapy.

Knowledge of the mechanisms by which the immune system interacts with cancer as it develops is increasing rapidly. From this field, cancer immunotherapy has emerged as one of the most exciting and promising approaches to treating cancer. These developments have translated into medical breakthroughs for many cancer patients, although the high prevalence of non-responders and adverse reactions reveals that there are still significant challenges to overcome.

This collection features research and reviews on key topics in the field topics such as CAR-T cell therapies, antibody biomarkers, adverse events and new drug mechanisms. All articles are free to read online.

We hope you enjoy reading this collection of articles and we encourage you to share this using the hashtag #WorldCancerDay and looping in @CEIjournal, @discovimmunol and @IMTadvances.

Clinical & Experimental Immunology, Immunotherapy Advances and Discovery Immunology are the official journals of the British Society for Immunology. Profits derived from the sale of the journals are invested back into the BSI, providing major financial support for the Society's activities. Support the journals and the Society by considering the journals for your next submission! 

Graphical abstract Monroy-Iglesias et al
Figure from 'Antibodies as biomarkers for cancer risk: a systematic review'

Clinical & Experimental Immunology

Research article

miR-132-3p regulates antibody-mediated complement-dependent cytotoxicity in colon cancer cells by directly targeting CD55 

Yu Fan, Juan Liao, Yu Wang, Zhu Wang, Hong Zheng, Yanping Wang

Research article

Antinuclear antibody (ANA) status predicts immune-related adverse events in liver cancer patients undergoing anti-PD-1 therapy 

Shu-Jung Hsu, Yen-Cheng Chao, Xia-Hui Lin, Hua-Hua Liu, Yang Zhang, Wei-Feng Hong, Mao-Pei Chen, Xin Xu, Lan Zhang, Zheng-Gang Ren, Shi-Suo Du, Rong-Xin Chen

Research article

Tumor gene signatures that correlate with release of extracellular vesicles shape the immune landscape in head and neck squamous cell carcinoma 

Isabella Kallinger, Dominique S Rubenich, Alicja Głuszko, Aditi Kulkarni, Gerrit Spanier, Steffen Spoerl, Juergen Taxis, Hendrik Poeck, Mirosław J Szczepański, Tobias Ettl, Torsten E Reichert, Johannes K Meier, Elizandra Braganhol, Robert L Ferris, Theresa L Whiteside, Nils Ludwig

Research article

Efficacy of anti-programmed cell death protein 1 monoclonal antibody combined with bevacizumab and/or Pseudomonas aeruginosa injection in transplanted tumor of mouse forestomach carcinoma cell gastric cancer in mice and its mechanism in regulating tumor immune microenvironment 

Xiangyong Liu, Chao Yan, Aijie Yang, Enhao Yu, Jie Yu, Chunyang Zhou, Yun Wang, Kai Wang, Ying Sun, Yufeng Cheng

Research article

Panobinostat enhances NK cell cytotoxicity in soft tissue sarcoma

Xiuxia Lu, Mengmeng Liu, Jing Yang, Yi Que, Xing Zhang

Review

Antibodies as biomarkers for cancer risk: a systematic review

Maria J Monroy-Iglesias, Silvia Crescioli, Kerri Beckmann, Nga Le, Sophia N Karagiannis, Mieke Van Hemelrijck, Aida Santaolalla

Review

Immunotherapeutic targeting of activating natural killer cell receptors and their ligands in cancer

Matthias Peipp, Katja Klausz, Ammelie Svea Boje, Tobias Zeller, Stefan Zielonka, Christian Kellner

Review

Does CCL19 act as a double-edged sword in cancer development?

Arezoo Gowhari Shabgah, Zaid Mahdi Jaber Al-Obaidi, Heshu Sulaiman Rahman, Walid Kamal Abdelbasset, Wanich Suksatan, Dmitry O Bokov, Lakshmi Thangavelu, Abduladheem Turki Jalil, Farhad Jadidi-Niaragh, Hamed Mohammadi, Kazem Mashayekhi, Jamshid Gholizadeh Navashenaq

Graphical abstract Kennedy et al
Figure from 'Migration of stem-like CD8 T cells between tissue microenvironments underpins successful anti-tumour immune responses''

Discovery Immunology

Review

Migration of stem-like CD8 T cells between tissue microenvironments underpins successful anti-tumour immune responses

Bethany C Kennedy, Isaac Dean, David R Withers

Review

The link between T cell activation and development of functionally useful tumour-associated high endothelial venules 

Stefan Milutinovic, Awen Gallimore

Review

What do cancer-specific T cells ‘see’?

Sabaria Shah, Abdullah Al-Omari, Katherine W Cook, Samantha J Paston, Lindy G Durrant, Victoria A Brentville

Research article

NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression

Sophie Curio, Sarah C Edwards, Toshiyasu Suzuki, Jenny McGovern, Chiara Triulzi, Nagisa Yoshida, Gustav Jonsson, Teresa Glauner, Damiano Rami, Robert Wiesheu, Anna Kilbey, Rachel Violet Purcell, Seth B Coffelt, Nadia Guerra

Graphical abstract Silla
Figure from 'Peripheral blood persistence and expansion of transferred non-genetically modified Natural Killer cells might not be necessary for clinical activity.

​Immunotherapy Advances

Review

Peripheral blood persistence and expansion of transferred non-genetically modified Natural Killer cells might not be necessary for clinical activity 

Lucia Silla

Review

DC-targeting lentivectors for cancer immunotherapy 

Ester Gea-Mallorquí, Sarah Rowland-Jones

Review

Combination therapies for the optimisation of Bispecific T-cell Engagers in cancer treatment 

Winston M Zhu, Mark R Middleton

Review

Balancing the good and the bad: controlling immune-related adverse events versus anti-tumor responses in cancer patients treated with immune checkpoint inhibitors

Guilherme Ferreira de Britto Evangelista, Amanda Braga Figueiredo, Milton José de Barros e Silva, Kenneth J Gollob

Research article

Blockade of innate inflammatory cytokines TNFα, IL-1β, or IL-6 overcomes virotherapy-induced cancer equilibrium to promote tumor regression 

Michael J Walsh, Lestat R Ali, Patrick Lenehan, Courtney T Kureshi, Rakeeb Kureshi, Michael Dougan, David M Knipe, Stephanie K Dougan

Research article

Characterization of sabatolimab, a novel immunotherapy with immuno-myeloid activity directed against TIM-3 receptor

Stephanie Schwartz, Nidhi Patel, Tyler Longmire, Pushpa Jayaraman, Xiaomo Jiang, Hongbo Lu, Lisa Baker, Janelle Velez, Radha Ramesh, Anne-Sophie Wavreille, Melanie Verneret, Hong Fan, Tiancen Hu, Fangmin Xu, John Taraszka, Marc Pelletier, Joy Miyashiro, Mikael Rinne, Glenn Dranoff, Catherine Sabatos-Peyton, Viviana Cremasco

Clinical & Experimental Immunology, Immunotherapy Advances and Discovery Immunology are the official journals of the British Society for Immunology. Profits derived from the sale of the journals are invested back into the BSI, providing major financial support for the Society's activities.

Support the BSI, submit your work now:

Discovery Immunology

Immunotherapy Advances

Clinical & Experimental Immunology