The 2025 Nobel Prize in Physiology or Medicine has been awarded to Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi for their discoveries concerning peripheral immune tolerance. Their discovery and research of regulatory T cells, cells that keep our immune system from attacking our own body, could lead to the development of new treatments for autoimmune diseases, treatments for cancer and may help in reducing complications for transplants.
To celebrate their achievement, we have collected papers on peripheral immune tolerance from all three of the BSI’s journals, Immunotherapy Advances, Clinical & Experimental Immunology and Discovery Immunology. We are proud to be able to contribute to such a vital part of immunology research.
As part of this virtual issue, we have also included the paper ‘Treg-based immunotherapy for antigen-specific immune suppression and stable tolerance induction: a perspective’ published in Immunotherapy Advances by prize winner, Shimon Sakaguchi.
We welcome any further research on this topic and thank our authors for choosing our journals.
Immunotherapy Advances
Treg-based immunotherapy for antigen-specific immune suppression and stable tolerance induction: a perspective, Immunotherapy Advances, Volume 3, Issue 1, 2023,
By Shimon Sakaguchi, Ryoji Kawakami, Norihisa Mikami,
Efficacy of PD-1 checkpoint inhibitor therapy in melanoma and beyond: are peripheral T cell phenotypes the key?, Immunotherapy Advances, Volume 3, Issue 1, 2023,
By Katie R Flaherty, Stephanie Kucykowicz, Johannes Schroth, Will Traves, Kyle T Mincham, George E Finney,
CTLA-4—two pathways to anti-tumour immunity? Immunotherapy Advances, Volume 5, Issue 1, 2025,
By Frank J Ward, Paul T Kennedy, Farah Al-Fatyan, Lekh N Dahal, Rasha Abu-Eid
Stratification of PD-1 blockade response in melanoma using pre-and post-treatment immunophenotyping of peripheral blood, Immunotherapy Advances, Volume 3, Issue 1, 2023,
By Natalie M Edner, Elisavet Ntavli, Lina Petersone, Chun Jing Wang, Astrid Fabri, Alexandros Kogimtzis, Vitalijs Ovcinnikovs, Ellen M Ross, Frank Heuts, Yassin Elfaki, Luke P Houghton, Toby Talbot, Amna Sheri, Alexandra Pender, David Chao, Lucy S K Walker
Clinical & Experimental Immunology
Therapeutic opportunities for regulatory T-cell enhancing approaches, Clinical and Experimental Immunology, Volume 211, Issue 2, February 2023, Pages 93–95,
By David F Tough, Giovanna Lombardi
Compartment-driven imprinting of intestinal CD4 T cells in inflammatory bowel disease and homeostasis, Clinical and Experimental Immunology, Volume 214, Issue 3, December 2023, Pages 235–248
By Lisanne Lutter, José J M ter Linde, Eelco C Brand, David P Hoytema van Konijnenburg, Britt Roosenboom, Carmen Horjus Talabur-Horje, Bas Oldenburg, Femke van Wijk,
HLA-DR expressing lymph node fibroblasts maintain FoxP3+ regulatory T cells and are reduced in rheumatoid arthritis, Clinical and Experimental Immunology, 2025
By Aoife M O’Byrne, Cristoforo Grasso, Charlotte M de Winde, Aleksandra M Mikula, Catarina Gago da Graça, Johanna F Semmelink, Ester B M Remmerswaal, Janne W Bolt, Marleen G H van de Sande, Reina E Mebius, Lisa G M van Baarsen
The immune landscape of the inflamed joint defined by spectral flow cytometry, Clinical and Experimental Immunology, Volume 218, Issue 3, December 2024, Pages 221–241,
By Meryl H Attrill, Diana Shinko, Vicky Alexiou, Melissa Kartawinata, CHARMS study , JIAP study , Lucy R Wedderburn, Anne M Pesenacker
Discovery Immunology
Identification of a transcription factor network regulating anti-TNF mediated IL10 expression in human CD4+ T cells, Discovery Immunology, Volume 3, Issue 1, 2024,
By Giovanni A M Povoleri, Michael L Ridley, Rebecca J Marrow, Sylvine Lalnunhlimi, Sarah E Ryan, Audrey Kelly, Paul Lavender, Leonie S Taams
Spectrum of Treg and self-reactive T cells: single cell perspectives from old friend HTLV-1, Discovery Immunology, Volume 3, Issue 1, 2024,
By Masahiro Ono, Yorifumi Satou
The sedoheptulose kinase CARKL controls T-cell cytokine outputs and migration by promoting metabolic reprogramming, Discovery Immunology, Volume 3, Issue 1, 2024,
By Michelangelo Certo, Jennifer Niven, Robert Haas, Paula Rudzinska, Joanne Smith, Danilo Cucchi, Jose R Hombrebueno, Claudio Mauro